Gene Symbol | MYLK2 |
---|---|
Entrez Gene | 85366 |
Alt Symbol | KMLC, MLCK, MLCK2, skMLCK |
Species | Human |
Gene Type | protein-coding |
Description | myosin light chain kinase 2 |
Other Description | myosin light chain kinase 2, skeletal muscle|myosin light chain kinase 2, skeletal/cardiac muscle |
Swissprots | Q96I84 Q569L1 Q9H1R3 |
Accessions | EAW76414 EAW76415 EAW76416 EAW76417 Q9H1R3 AF325549 AAK15494 AJ272502 CAC81354 BC007753 AAH07753 BC069627 AAH69627 BC092413 AAH92413 BC127622 AAI27623 BX647635 F22840 XR_244155 NM_033118 NP_149109 |
Function | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
Subcellular Location | Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. |
Tissue Specificity | Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue. |
Top Pathways | Focal adhesion, Calcium signaling pathway, Vascular smooth muscle contraction, Gastric acid secretion, Oxytocin signaling pathway |