FNBP1L

Gene Symbol FNBP1L
Entrez Gene 54874
Alt Symbol C1orf39, TOCA1
Species Human
Gene Type protein-coding
Description formin binding protein 1-like
Other Description formin-binding protein 1-like|toca-1|transducer of Cdc42-dependent actin assembly 1|transducer of Cdc42-dependent actin assembly protein 1
Swissprots Q9NXG1 Q6R4Q4 Q6B097 Q6P653 J3QSS4 Q5T0N5 Q5T0N6
Accessions CAC22513 EAW73069 EAW73070 EAW73071 Q5T0N5 AK000282 BAA91051 AK025526 AK026988 AK296767 BAG59347 AK299760 BAG61649 AK299943 BAG61773 AK315981 BAH14352 AY514449 AAR98814 BC062477 AAH62477 BC074891 AAH74891 BC074892 AAH74892 BX476921 DB219295 DW423801 XM_011541625 XP_011539927 XM_011541626 XP_011539928 NM_001024948 NP_001020119 NM_001164473 NP_001157945 NM_017737 NP_060207
Function Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

TOCA-1 (E-17) - sc-103902 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TOCA-1 (N-17) - sc-103903 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FNBP1L antibody - ab67310 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FNBP1L antibody (ab67310) at 1 µg/mlLane 1 : Mouse brain tissue lysate with no blocking peptideLane 2 : Mouse brain tissue lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-FNBP1L antibody - ab67311 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FNBP1L antibody (ab67311) at 0.5 µg/mlLane 1 : Human brain tissue lysate with no blocking peptideLane 2 : Human brain tissue lysate with blocking peptideLysates/proteins at 15 µg/ml per lane.

Anti-FNBP1L antibody - ab129633 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FNBP1L antibody (ab129633) at 1/100 dilution + Mouse lung tissue lysate at 35 µg

Anti-FNBP1L antibody - ab124277 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1: Staining of FNBP1L in Jurkat whole cell lysate immunoprecipitated using ab124277 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: control IgG.

Anti-TOCA1 / FNBP1L Antibody (C-Terminus) IHC-plus™ - LS-B3214 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FNBP1L / Toca-1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3214 concentration 5 ug/ml.

Anti-TOCA1 / FNBP1L Antibody (N-Terminus) - LS-C53220 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 50 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 ug/ml.

Anti-TOCA1 / FNBP1L Antibody (aa450-500) - LS-C290144 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Toca-1 by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-Toca-1 used at a dilution of 1:1000 (1 ug/mg).

Anti-TOCA1 / FNBP1L Antibody (aa349-377, AP) - LS-C235331 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa349-377, APC) - LS-C235332 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa349-377, Biotin) - LS-C235334 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa349-377, FITC) - LS-C235333 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa349-377, PE) - LS-C235335 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa349-377, Azide-free, HRP) - LS-C248997 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa50-100) - LS-C290142 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TOCA1 / FNBP1L Antibody (aa349-377) - LS-C166195 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FNBP1L Antibody western blot of mouse lung tissue lysates (35 ug/lane). The FNBP1L antibody detected the FNBP1L protein (arrow).

Anti-TOCA1 / FNBP1L Antibody (aa348-377) - LS-C321407 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

FNBP1L Antibody - NBP1-76846 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FNBP1L Antibody [NBP1-76846] - Human brain tissue lysate in (A) the absence and (B) the presence of blocking peptide with FNBP1L antibody at 0.5 ug/mL.

FNBP1L Antibody - NBP1-50455 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FNBP1L Antibody [NBP1-50455] - Western blot analysis of TOCA-1 in mouse brain tissue lysate with in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 1 ug/ml. Below: Immunohistochemistry of TOCA-1 in human brain tissue with TOCA-1 antibody at 2.5 ug/ml.

FNBP1L Antibody - NBP1-80569 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FNBP1L Antibody [NBP1-80569] - Whole cell lysate from Jurkat (15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and HeLa (H; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-Toca-1 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. Toca-1 was also immunoprecipitated by rabbit anti-Toca-1 antibody NBP1-80563 which recognizes an upstream epitope.

FNBP1L Antibody - NBP1-76845 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

FNBP1L Antibody (1E6) - H00054874-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E6
Western Blot: FNBP1L Antibody (1E6) [H00054874-M01] - FNBP1L monoclonal antibody (M01), clone 1E6. Analysis of FNBP1L expression in HepG2.

FNBP1L/TOCA1 Polyclonal Antibody - bs-11841R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FNBP1L/TOCA1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11841R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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