| Gene Symbol |
FNBP1L
|
| Entrez Gene |
54874
|
| Alt Symbol |
C1orf39, TOCA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
formin binding protein 1-like
|
| Other Description |
formin-binding protein 1-like|toca-1|transducer of Cdc42-dependent actin assembly 1|transducer of Cdc42-dependent actin assembly protein 1
|
| Swissprots |
Q9NXG1 Q6R4Q4 Q6B097 Q6P653 J3QSS4 Q5T0N5 Q5T0N6
|
| Accessions |
CAC22513 EAW73069 EAW73070 EAW73071 Q5T0N5 AK000282 BAA91051 AK025526 AK026988 AK296767 BAG59347 AK299760 BAG61649 AK299943 BAG61773 AK315981 BAH14352 AY514449 AAR98814 BC062477 AAH62477 BC074891 AAH74891 BC074892 AAH74892 BX476921 DB219295 DW423801 XM_011541625 XP_011539927 XM_011541626 XP_011539928 NM_001024948 NP_001020119 NM_001164473 NP_001157945 NM_017737 NP_060207
|
| Function |
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|