FNBP1L

Gene Symbol FNBP1L
Entrez Gene 54874
Alt Symbol C1orf39, TOCA1
Species Human
Gene Type protein-coding
Description formin binding protein 1-like
Other Description formin-binding protein 1-like|toca-1|transducer of Cdc42-dependent actin assembly 1|transducer of Cdc42-dependent actin assembly protein 1
Swissprots Q9NXG1 Q6R4Q4 Q6B097 Q6P653 J3QSS4 Q5T0N5 Q5T0N6
Accessions CAC22513 EAW73069 EAW73070 EAW73071 Q5T0N5 AK000282 BAA91051 AK025526 AK026988 AK296767 BAG59347 AK299760 BAG61649 AK299943 BAG61773 AK315981 BAH14352 AY514449 AAR98814 BC062477 AAH62477 BC074891 AAH74891 BC074892 AAH74892 BX476921 DB219295 DW423801 XM_011541625 XP_011539927 XM_011541626 XP_011539928 NM_001024948 NP_001020119 NM_001164473 NP_001157945 NM_017737 NP_060207
Function Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

TOCA-1 CRISPR/Cas9 KO Plasmid (h) - sc-408893 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 HDR Plasmid (h) - sc-408893-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 Double Nickase Plasmid (h) - sc-408893-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 Double Nickase Plasmid (h2) - sc-408893-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 CRISPR Activation Plasmid (h) - sc-408893-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 CRISPR Activation Plasmid (h2) - sc-408893-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 Lentiviral Activation Particles (h) - sc-408893-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 Lentiviral Activation Particles (h2) - sc-408893-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TOCA-1 siRNA (h) - sc-88407 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TOCA-1 shRNA Plasmid (h) - sc-88407-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TOCA-1 shRNA (h) Lentiviral Particles - sc-88407-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU134311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8852 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8852 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FNBP1L siRNA (Human) - CRJ0285 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FNBP1L - MBS8212138 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human FNBP1L siRNA - orb270786 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FNBP1L shRNA Plasmid (Human) - CHJ0285 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FNBP1L miRNA 3'UTR clone - MiUTR4H-TG03586 from Creative biogene

Species Reactivities Human
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