Gene Symbol | EEF2K |
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Entrez Gene | 29904 |
Alt Symbol | HSU93850, eEF-2K |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic elongation factor 2 kinase |
Other Description | calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase|calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase|calmodulin-dependent protein kinase III|eEF-2 kinase|elongation factor-2 kinase|eukaroytic elongation factor 2 kinase|eukaryotic elongation factor-2 kinase |
Swissprots | O00418 Q8N588 |
Accessions | EAW50604 O00418 AK022569 AK308757 AW675420 BC032665 AAH32665 CA397138 DA556486 DA735877 DQ890896 ABM81822 DQ894050 ABM84976 U93850 AAB58270 XR_950786 XR_950787 NM_013302 NP_037434 |
Function | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
Top Pathways | Oxytocin signaling pathway, AMPK signaling pathway |
Active human EEF2K full length protein - ab84570 from Abcam
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Human EEF2K full length protein - ab153309 from Abcam
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Human EEF2K full length protein - ab187454 from Abcam
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EEF2K Antibody Blocking Peptide - LS-E3635 from LifeSpan Bioscience
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EEF2K Recombinant Protein - H00029904-P01 from Novus Biologicals
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EEF2K protein (His tag) - 80R-3972 from Fitzgerald
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EEF-2 kinase (1-725, His-tag) - AR51657PU-N from Acris Antibodies
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EEF-2 kinase (1-725, His-tag) - AR51657PU-S from Acris Antibodies
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EEF-2 kinase - P5544 from Acris Antibodies
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EEF2K fusion protein - ag4432 from Proteintech Group
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Recombinant Human Eukaryotic Elongation Factor-2 Kinase, GST-tagged - EEF2K-1879H from Creative Biomart
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Recombinant Human EEF2K, GST-tagged, Active - EEF2K-296H from Creative Biomart
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Recombinant Human EEF2K - EEF2K-27779TH from Creative Biomart
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Recombinant Human eukaryotic elongation factor-2 kinase, His-tagged - EEF2K-614H from Creative Biomart
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Recombinant Human EEF2K (Active), GST-tagged - EEF2K-1398H from Creative Biomart
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EF2tide - 12-560 from EMD Millipore
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eEF-2K Protein, active, 250 µg - 14-654M from EMD Millipore
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EEF2K (pS366) Blocking Peptide - CBP3468 from Cohesion Biosciences
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eEF2K (P360) Peptide - BS1100P from Bioworld Technology
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eEF2K (G358) Peptide - BS3764P from Bioworld Technology
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p-eEF2K (S366) Peptide - BS4060P from Bioworld Technology
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Recombinant Human Eukaryotic elongation factor 2 kinase(EEF2K) - CSB-YP007435HU CSB-EP007435HU CSB-BP007435HU CSB-MP007435HU from Cusabio
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EEF2K, 1-725aa, Human, His tag, E.coli - ATGP2837 from ATGen
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EEF2K Blocking Peptide - CBP4391 from Cohesion Biosciences
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eEF2K (C-terminus) - EX4665 from ECM Biosciences
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