Gene Symbol | EEF2K |
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Entrez Gene | 29904 |
Alt Symbol | HSU93850, eEF-2K |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic elongation factor 2 kinase |
Other Description | calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase|calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase|calmodulin-dependent protein kinase III|eEF-2 kinase|elongation factor-2 kinase|eukaroytic elongation factor 2 kinase|eukaryotic elongation factor-2 kinase |
Swissprots | O00418 Q8N588 |
Accessions | EAW50604 O00418 AK022569 AK308757 AW675420 BC032665 AAH32665 CA397138 DA556486 DA735877 DQ890896 ABM81822 DQ894050 ABM84976 U93850 AAB58270 XR_950786 XR_950787 NM_013302 NP_037434 |
Function | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
Top Pathways | Oxytocin signaling pathway, AMPK signaling pathway |
eEF2K CRISPR/Cas9 KO Plasmid (h) - sc-402166 from Santa Cruz Biotechnology
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eEF2K HDR Plasmid (h) - sc-402166-HDR from Santa Cruz Biotechnology
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eEF2K Double Nickase Plasmid (h) - sc-402166-NIC from Santa Cruz Biotechnology
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eEF2K Double Nickase Plasmid (h2) - sc-402166-NIC-2 from Santa Cruz Biotechnology
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eEF2K CRISPR Activation Plasmid (h) - sc-402166-ACT from Santa Cruz Biotechnology
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eEF2K CRISPR Activation Plasmid (h2) - sc-402166-ACT-2 from Santa Cruz Biotechnology
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eEF2K Lentiviral Activation Particles (h) - sc-402166-LAC from Santa Cruz Biotechnology
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eEF2K Lentiviral Activation Particles (h2) - sc-402166-LAC-2 from Santa Cruz Biotechnology
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eEF2K siRNA (h) - sc-39011 from Santa Cruz Biotechnology
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eEF2K shRNA Plasmid (h) - sc-39011-SH from Santa Cruz Biotechnology
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eEF2K shRNA (h) Lentiviral Particles - sc-39011-V from Santa Cruz Biotechnology
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EEF2K RNAi - H00029904-R03 from Novus Biologicals
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MISSION® esiRNA - EHU033871 from Sigma-Aldrich
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MISSION® esiRNA - EHU072281 from Sigma-Aldrich
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MISSION® esiRNA - EHU031951 from Sigma-Aldrich
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MISSION® siRNA - SIHK0656 from Sigma-Aldrich
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MISSION® siRNA - SIHK0655 from Sigma-Aldrich
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MISSION® siRNA - SIHK0654 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1243 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1243 from Sigma-Aldrich
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EEF2K siRNA (Human) - CRH9259 from Cohesion Biosciences
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EEF2K - MBS8202960 from MyBioSource
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shRNA set against Human EEF2K (NM_013302.3) - SHH283349 from Creative biogene
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shRNA set against Human EEF2K(NM_013302.3) - SHH024923 from Creative biogene
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EEF2K shRNA Plasmid (Human) - CHH9259 from Cohesion Biosciences
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