FFAR1

Gene Symbol FFAR1
Entrez Gene 2864
Alt Symbol FFA1R, GPCR40, GPR40
Species Human
Gene Type protein-coding
Description free fatty acid receptor 1
Other Description G protein-coupled receptor 40|G-protein coupled receptor 40
Swissprots O14842 Q4VBL4 Q0VAS2
Accessions AAB86710 ABY87912 CAD83804 O14842 BC039436 BC095536 AAH95536 BC120943 AAI20944 BC120944 AAI20945 EF611308 ABQ96386 NM_005303 NP_005294
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:24130766}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059}; Multi-pass membrane protein {ECO:0000269|PubMed:25043059}.
Tissue Specificity Detected in brain and pancreas. Detected in pancreatic beta cells. {ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:16289108}.

GPR40 (C-17) - sc-28417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GPR40 (E-20) - sc-28415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GPR40 (FL-300) - sc-32905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GPR40 (Y-17) - sc-28416 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GPCR GPR40 antibody - ab32889 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-GPCR GPR40 antibody (ab32889) at 0.03 µg/ml + Human breast lysate (35µg protein in RIPA buffer).

Anti-GPCR GPR40 antibody - C-terminal - ab188920 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, neurons tissue labeling GPCR GPR40 with ab188920 at 9 µg/ml.

Anti-GPCR GPR40 antibody - C-terminal - ab170633 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR40 antibody - C-terminal (ab170633) at 1/100 dilution + CEM cell line lysates at 35 µg

Anti-GPCR GPR40 antibody - Cytoplasmic domain - ab188929 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labeling GPCR GPR40 with ab188929 at 10 µg/ml.

Anti-FFAR1 / GPR40 Antibody (Internal, clone EP4632) IHC-plus™ - LS-B9444 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EP4632]
Anti-FFAR1 / GPR40 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FFAR1 / GPR40 Antibody IHC-plus™ - LS-B4078 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GPR40 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4078 concentration 10 ug/ml.

Anti-FFAR1 / GPR40 Antibody - LS-C146689 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa280-300, AP) - LS-C214187 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa289-300) - LS-C54932 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.01 ug/ml) staining of Human Breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-FFAR1 / GPR40 Antibody (Trp224) - LS-C177198 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GPR40 (W224) pAb in extracts from COS-7 cells treated with forskolin 40nM 30'.

Anti-FFAR1 / GPR40 Antibody (aa280-300, APC) - LS-C214188 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa280-300, Biotin) - LS-C214189 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa280-300, FITC) - LS-C214190 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa280-300, Azide-free, HRP) - LS-C214191 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1599 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-FFAR1 / GPR40 Antibody (aa280-300, PE) - LS-C214192 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa275-300) - LS-C166121 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FFAR1 Antibody western blot of CEM cell line lysates (35 ug/lane). The FFAR1 antibody detected the FFAR1 protein (arrow).

Anti-FFAR1 / GPR40 Antibody (aa280-300) - LS-C321359 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FFAR1 / GPR40 Antibody (aa185-234) - LS-C120652 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using FFAR1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FFAR1 / GPR40 Antibody (C-Terminus) IHC-plus™ - LS-A1595 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FFAR1 / GPR40 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FFAR1/GPR40 Antibody (EP4632) - NBP1-95534 from Novus Biologicals

Host Rabbit
Clonality Monoclonal
Clone EP4632
Western Blot: GPR40 Antibody (EP4632) [NBP1-95534] (A) AR42J, (B) BxPC-3, © HeLa, and (D) Neuro-2a cell lysates.
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