| Gene Symbol |
FFAR1
|
| Entrez Gene |
2864
|
| Alt Symbol |
FFA1R, GPCR40, GPR40
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
free fatty acid receptor 1
|
| Other Description |
G protein-coupled receptor 40|G-protein coupled receptor 40
|
| Swissprots |
O14842 Q4VBL4 Q0VAS2
|
| Accessions |
AAB86710 ABY87912 CAD83804 O14842 BC039436 BC095536 AAH95536 BC120943 AAI20944 BC120944 AAI20945 EF611308 ABQ96386 NM_005303 NP_005294
|
| Function |
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:24130766}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059}; Multi-pass membrane protein {ECO:0000269|PubMed:25043059}.
|
| Tissue Specificity |
Detected in brain and pancreas. Detected in pancreatic beta cells. {ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:16289108}.
|
![Western Blot: GPR40 Overexpression Lysate (Adult Normal) [NBL1-10681] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GPR40.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2632_GPR40%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10681-img0002.jpg)