FFAR1

Gene Symbol FFAR1
Entrez Gene 2864
Alt Symbol FFA1R, GPCR40, GPR40
Species Human
Gene Type protein-coding
Description free fatty acid receptor 1
Other Description G protein-coupled receptor 40|G-protein coupled receptor 40
Swissprots O14842 Q4VBL4 Q0VAS2
Accessions AAB86710 ABY87912 CAD83804 O14842 BC039436 BC095536 AAH95536 BC120943 AAI20944 BC120944 AAI20945 EF611308 ABQ96386 NM_005303 NP_005294
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:24130766}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059}; Multi-pass membrane protein {ECO:0000269|PubMed:25043059}.
Tissue Specificity Detected in brain and pancreas. Detected in pancreatic beta cells. {ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:16289108}.

GPR40 CRISPR/Cas9 KO Plasmid (h) - sc-401434 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 HDR Plasmid (h) - sc-401434-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 Double Nickase Plasmid (h) - sc-401434-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 Double Nickase Plasmid (h2) - sc-401434-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 CRISPR Activation Plasmid (h) - sc-401434-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 CRISPR Activation Plasmid (h2) - sc-401434-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 Lentiviral Activation Particles (h) - sc-401434-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 Lentiviral Activation Particles (h2) - sc-401434-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 siRNA (h) - sc-105408 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR40 shRNA Plasmid (h) - sc-105408-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR40 shRNA (h) Lentiviral Particles - sc-105408-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FFAR1/GPR40 RNAi - H00002864-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8635 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8635 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1104 from Sigma-Aldrich

Category ZFN Kit
Prices $6,000.00
Sizes 1 kt

FFAR1 siRNA (Human) - CRH1923 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FFAR1 - MBS8202573 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPR40 CRISPR/Cas9 KO Plasmid (h2) - sc-401434-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPR40 HDR Plasmid (h2) - sc-401434-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human FFAR1 (NM_005303.2) - SHH294229 from Creative biogene

Category siRNA
Species Reactivities Human

Human FFAR1 siRNA - orb262425 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FFAR1 shRNA Plasmid (Human) - CHH1923 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FFAR1 miRNA 3'UTR clone - MiUTR4H-TG03521 from Creative biogene

Species Reactivities Human
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