KDM4A

Gene Symbol KDM4A
Entrez Gene 9682
Alt Symbol JHDM3A, JMJD2, JMJD2A, TDRD14A
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 4A
Other Description jmjC domain-containing histone demethylation protein 3A|jumonji C domain-containing histone demethylase 3A|jumonji domain containing 2|jumonji domain containing 2A|jumonji domain-containing protein 2A|lysine-specific demethylase 4A|tudor domain containing 14A
Swissprots O75164 Q5VVB1
Accessions CCQ43452 EAX07085 O75164 AB014577 BAA31652 AK294596 BAG57784 AK300039 BAG61850 AK310295 BC002558 AAH02558 BP198064 CA944984 CN361683 Z70219 XM_005271354 XP_005271411 XM_005271355 XP_005271412 XM_005271356 XP_005271413 XM_011542467 XP_011540769 NM_014663 NP_055478
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15927959}.

KDM4A 293 Cell Lysate - 402083 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Lysine (K)-specific Demethylase 4A/KDM4A/JMJD2A Overexpression Lysate (Native) - NBL1-12103 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

KDM4A Over-expression Lysate Product - GWB-EBDE3E from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

KDM4A-knockout Cell lysate - LC810294 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human KDM4A Knockdown Stable Cell Line - CSC-DC008045 from Creative biogene

Category Cell Line
Species Human

Human KDM4A Knockout Cell Line-HeLa - CSC-RT0759 from Creative biogene

Category Cell Line
Species Human

KDM4A KO Cell Lysate-HeLa - CLKO-0263 from Creative biogene

Category Cell Lysate
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