RSPO1

Gene Symbol RSPO1
Entrez Gene 284654
Alt Symbol CRISTIN3, RSPO
Species Human
Gene Type protein-coding
Description R-spondin 1
Other Description R-spondin homolog|R-spondin-1|roof plate-specific spondin-1
Swissprots Q5T0F2 Q8N7L5 Q0H8S6 A2A420 Q14C72 Q2MKA7
Accessions CBX87729 EAX07331 Q2MKA7 AK098225 BAC05263 BC114966 AAI14967 CA438631 DB273983 DQ165084 ABA54597 DQ165085 ABA54598 DQ318235 ABC54570 XM_006710583 XP_006710646 NM_001038633 NP_001033722 NM_001242908 NP_001229837 NM_001242909 NP_001229838 NM_001242910 NP_001229839 NM_173640
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. {ECO:0000269|PubMed:16109882, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.

Anti-RSPO1 antibody - ab106556 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-RSPO1 antibody (ab106556) at 1 µg/mlLane 2 : Anti-RSPO1 antibody (ab106556) at 2 µg/mlLane 1 : Rat spleen tissue lysateLane 2 : Rat spleen tissue lysateLysates/proteins at 15 µg per lane.

Anti-RSPO1 antibody - ab118598 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-RSPO1 antibody (ab118598) at 1 µg/mlLane 2 : Anti-RSPO1 antibody (ab118598) at 2 µg/mlLane 1 : Rat spleen tissue lysate Lane 2 : Rat spleen tissue lysate

Anti-RSPO1 antibody [7A6] - ab81600 from Abcam

Host Mouse
Clonality Monoclonal
Clone 7A6
All lanes : Anti-RSPO1 antibody [7A6] (ab81600) at 1/500 dilutionLane 1 : Recombinant RSPO1 Lane 2 : RSPO1 (aa21-263)-hIgGFc transfected HEK293 cell lysate

Anti-RSPO1 / RSPO Antibody (N-Terminus) IHC-plus™ - LS-B4605 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RSPO1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4605 concentration 5 ug/ml.

Anti-RSPO1 / RSPO Antibody (aa136-262) - LS-C296290 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RSPO1 / RSPO.

Anti-RSPO1 / RSPO Antibody (aa21-135) - LS-C296288 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RSPO1 / RSPO.

Anti-RSPO1 / RSPO Antibody (aa136-262, FITC) - LS-C301979 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RSPO1 / RSPO Antibody (aa21-135, FITC) - LS-C302280 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RSPO1 / RSPO Antibody (aa21-135) - LS-C296291 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RSPO1 / RSPO.

Anti-RSPO1 / RSPO Antibody (aa21-263, clone 2B11) - LS-C340636 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RSPO1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO1.

Anti-RSPO1 / RSPO Antibody (aa21-263, clone 2F10) - LS-C339218 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RSPO1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO1.

Anti-RSPO1 / RSPO Antibody (aa21-135) - LS-C315031 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant RSPO1 / RSPO.

Anti-RSPO1 / RSPO Antibody (aa21-263, clone 1C3) - LS-C339316 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C3
IHC of paraffin-embedded Human colon tissue using anti-RSPO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-RSPO1 / RSPO Antibody (aa21-263, clone 11A9) - LS-C339254 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11A9
IHC of paraffin-embedded Human lymph node tissue using anti-RSPO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-RSPO1 / RSPO Antibody (aa31-263) - LS-C184885 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-RSPO1 / RSPO Antibody (clone 7A6) - LS-C108726 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7A6
Western blot using R-spondin1 mouse monoclonal antibody against recombinant R-spondin1 protein (1) and R-spondin1(aa21-263)-hIgGFc transfected HEK293 cell lysate(2).

Anti-RSPO1 / RSPO Antibody (aa136-262, Biotin) - LS-C299650 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RSPO1 / RSPO Antibody (aa21-135, Biotin) - LS-C300020 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

R-Spondin 1 Antibody - AF3474 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry R-Spondin 1 Antibody

R-Spondin 1 Antibody (422407) - MAB4658 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 422407

R-Spondin 1 Antibody - NBP1-77354 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: R-Spondin 1 Antibody [NBP1-77354] - Analysis in human heart tissue lysate with antibody at (A) 1 and (B) 2 ug/mL.

R-Spondin 1 Antibody (852010) - MAB3474 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 852010
Recombinant Mouse R‑Spondin 1 (Catalog # 7150-RS) co-stimulates beta -catenin response in the HEK293T human embryonic kidney cell line in a dose-dependent manner (orange line). beta -Catenin Response elicited by Recombinant Mouse R‑Spondin 1 (500 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse R‑Spondin 1 Mono­clonal Antibody (Catalog # MAB3474) in the presence of 5 ng/mL of Recombinant Mouse Wnt-3a (Catalog # 1324-WN). The ND50 is typically 0.4‑2 μg/mL.

R-Spondin 1 Antibody [Unconjugated] - AF4645 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

R-Spondin 1 Antibody - NBP1-92357 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

R-Spondin 1 Antibody - 44820002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: R-Spondin 1 Antibody [44820002]
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