RSPO1

Gene Symbol	RSPO1
Entrez Gene	284654
Alt Symbol	CRISTIN3, RSPO
Species	Human
Gene Type	protein-coding
Description	R-spondin 1
Other Description	R-spondin homolog|R-spondin-1|roof plate-specific spondin-1
Swissprots	Q5T0F2 Q8N7L5 Q0H8S6 A2A420 Q14C72 Q2MKA7
Accessions	CBX87729 EAX07331 Q2MKA7 AK098225 BAC05263 BC114966 AAI14967 CA438631 DB273983 DQ165084 ABA54597 DQ165085 ABA54598 DQ318235 ABC54570 XM_006710583 XP_006710646 NM_001038633 NP_001033722 NM_001242908 NP_001229837 NM_001242909 NP_001229838 NM_001242910 NP_001229839 NM_173640
Function	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. {ECO:0000269|PubMed:16109882, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
Subcellular Location	Secreted {ECO:0000250}.
Tissue Specificity	Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CRISTIN3 Gene - orb91584 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

RSPO1 - MBS1274803 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC114966

Human RSPO1 ORF Clone(NM_001038633.3) - CDCL174326 from Creative Biomart Species Human Accession NM_001038633.3

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone in cloning vector - HG11083-M from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid - HG11083-UT from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11083-NY from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11083-ACG from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11083-NH from Sino Biological Species Human

Human RSPO1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11083-M-F from Sino Biological Species Human Accession NM_001038633.2

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11083-CH from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11083-NF from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11083-NM from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11083-CF from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11083-CM from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11083-ACR from Sino Biological Species Human

Human R-Spondin 1/RSPO1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11083-CY from Sino Biological Species Human

Human RSPO1 ORF Clone (BC114966) - CDCS406927 from Creative biogene Species Human Accession Q2MKA7

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