RSPO1

Gene Symbol	RSPO1
Entrez Gene	284654
Alt Symbol	CRISTIN3, RSPO
Species	Human
Gene Type	protein-coding
Description	R-spondin 1
Other Description	R-spondin homolog|R-spondin-1|roof plate-specific spondin-1
Swissprots	Q5T0F2 Q8N7L5 Q0H8S6 A2A420 Q14C72 Q2MKA7
Accessions	CBX87729 EAX07331 Q2MKA7 AK098225 BAC05263 BC114966 AAI14967 CA438631 DB273983 DQ165084 ABA54597 DQ165085 ABA54598 DQ318235 ABC54570 XM_006710583 XP_006710646 NM_001038633 NP_001033722 NM_001242908 NP_001229837 NM_001242909 NP_001229838 NM_001242910 NP_001229839 NM_173640
Function	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. {ECO:0000269|PubMed:16109882, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
Subcellular Location	Secreted {ECO:0000250}.
Tissue Specificity	Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RSPO1 full length protein - ab155744 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human RSPO1 protein fragment - ab155745 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

Human RSPO1 full length protein - ab134626 from Abcam Category Protein Source CHO Species Human

RSPO1 / RSPO Antibody Blocking Peptide - LS-E30705 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

R-Spondin 1 Blocking Peptide - NBP1-77354PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RSPO1 recombinant protein - GTX53852 from GeneTex Category Protein Prices $199.00 Sizes 20 μg Source CHO cells

RSPO1 Peptide - GTX85282-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human R-Spondin 1 - 4645-RS-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg31-Ala263

Recombinant Human R-Spondin 1, CF - 4645-RS-01M/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg31-Ala263

Recombinant Human R-Spondin 1, CF - 4645-RS-025/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg31-Ala263

Human CRISTIN3 protein - orb139605 from Biorbyt Category Protein Prices $162.00, $323.00, $731.00, $2,278.00, $3,732.00 Sizes 5 μg, 20 μg, 100 μg, 500 μg, 1 mg Source CHO Stable Cells Species Human

Human CRISTIN3 protein - orb83356 from Biorbyt Category Protein Prices $162.00, $323.00, $731.00 Sizes 5 μg, 20 μg, 100 μg Source Human Species Human

RSPO1 - AR31070PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source CHO cells Species Human

RSPO1 - AR31070PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source CHO cells Species Human

RSPO1 - AR31177PU-N from Acris Antibodies Category Protein Prices $320.00 Sizes 20 µg Source CHO cells Species Human

RSPO1 - P6137 from Acris Antibodies Category Protein Prices $580.00 Sizes 20 µg Species Human

RSPO1 Control Peptide - AP30742CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

R-Spondin-1, Recombinant Human - 213-10376-1 from RayBiotech Category Protein Prices $75.00 Sizes 1 µg Source CHO cells Species Human

Recombinant Human R-Spondin-1 - 213-10376-2 from RayBiotech Category Protein Prices $190.00 Sizes 2 µg Source CHO cells Species Human

R-Spondin-1, Human, Recombinant - 28-10280 from ARP American Research Products Category Protein Prices $99.00, $102.00, $199.00 Sizes 5 µg, 1 mg, 20 µg Source CHO cells Species Human

RSPO1 Peptide - 5171P from ProSci Category Peptide Species Human

R Spondin 1 (21-146) Recombinant Protein - 96-660 from ProSci Category Protein Prices $500.00 Sizes 50 µg Source HEK293 cells Species Human

Rspondin 1 Recombinant Protein - 96-658 from ProSci Category Protein Prices $500.00 Sizes 50 µg Source HEK293 cells Species Human

RSPO1 fusion protein - ag21858 from Proteintech Group Category Protein Source E. coli-derived, PET30a Species Human

Recombinant Human RSPO1, His tagged - RSPO1-2341H from Creative Biomart Category Protein Source Human Cells Species Human

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