| Gene Symbol |
RSPO1
|
| Entrez Gene |
284654
|
| Alt Symbol |
CRISTIN3, RSPO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
R-spondin 1
|
| Other Description |
R-spondin homolog|R-spondin-1|roof plate-specific spondin-1
|
| Swissprots |
Q5T0F2 Q8N7L5 Q0H8S6 A2A420 Q14C72 Q2MKA7
|
| Accessions |
CBX87729 EAX07331 Q2MKA7 AK098225 BAC05263 BC114966 AAI14967 CA438631 DB273983 DQ165084 ABA54597 DQ165085 ABA54598 DQ318235 ABC54570 XM_006710583 XP_006710646 NM_001038633 NP_001033722 NM_001242908 NP_001229837 NM_001242909 NP_001229838 NM_001242910 NP_001229839 NM_173640
|
| Function |
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. {ECO:0000269|PubMed:16109882, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.
|
