RSPO1

Gene Symbol	RSPO1
Entrez Gene	284654
Alt Symbol	CRISTIN3, RSPO
Species	Human
Gene Type	protein-coding
Description	R-spondin 1
Other Description	R-spondin homolog|R-spondin-1|roof plate-specific spondin-1
Swissprots	Q5T0F2 Q8N7L5 Q0H8S6 A2A420 Q14C72 Q2MKA7
Accessions	CBX87729 EAX07331 Q2MKA7 AK098225 BAC05263 BC114966 AAI14967 CA438631 DB273983 DQ165084 ABA54597 DQ165085 ABA54598 DQ318235 ABC54570 XM_006710583 XP_006710646 NM_001038633 NP_001033722 NM_001242908 NP_001229837 NM_001242909 NP_001229838 NM_001242910 NP_001229839 NM_173640
Function	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. {ECO:0000269|PubMed:16109882, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
Subcellular Location	Secreted {ECO:0000250}.
Tissue Specificity	Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RSPO1 / RSPO ELISA Kit (Sandwich ELISA) - LS-F6893 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 15.63-1000 pg/ml

Mouse RSPO1 / RSPO ELISA Kit (Sandwich ELISA) - LS-F7110 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 15.63-1000 pg/ml

Human R-Spondin 1 DuoSet ELISA - DY4645-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 31.20 - 2,000 pg/mL

R-Spondin 1 (RSPO1), Human, ELISA Kit - SEM171Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 5.8pg/mL Range 15.6-1,000pg/mL

R-Spondin 1, Human, ELISA Kit - E01R0030 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

R-spondin-1 (RSPO1), Human, ELISA Kit - CSB-EL020550HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

R-spondin-1, RSPO1, Human, ELISA Kit - E3285h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

R Spondin 1, ELISA Kit - MBS749065 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL

R-Spondin 1, ELISA Kit - MBS087296 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS107787 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS058640 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS752152 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS748847 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

R-Spondin 1, ELISA Kit - MBS749875 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS086583 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS745535 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS079178 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS070731 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS752207 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS106575 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS101726 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS077665 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS744291 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

R-Spondin 1, ELISA Kit - MBS750195 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 1, ELISA Kit - MBS746879 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

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