LNX1

Gene Symbol LNX1
Entrez Gene 84708
Alt Symbol LNX, MPDZ, PDZRN2
Species Human
Gene Type protein-coding
Description ligand of numb-protein X 1, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase LNX|PDZ domain-containing ring finger protein 2|multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX|numb-binding protein 1
Swissprots Q8N4C2 Q9BY20 Q8TBB1 Q96MJ7 Q4W5K7
Accessions AAY41000 EAX05450 EAX05451 Q8TBB1 AF237782 AAK15039 AK056823 BAB71291 AK294611 BAG57796 AY358326 AAQ88692 BC022983 AAH22983 BC034737 AAH34737 BC094772 DA154083 DA625539 DA854815 DA874715 DB159390 DQ893984 ABM84910 XM_005265785 XP_005265842 XM_005265786 XP_005265843 NM_001126328 NP_001119800 NM_032622 NP_116011
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed in heart, placenta, kidney, pancreas and brain. {ECO:0000269|PubMed:11521506}.

LNX1 (E-12) - sc-48024 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LNX1 (H-20) - sc-48025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LNX1 (H-54) - sc-134511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

LNX1 (U-21) - sc-133746 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Lnx1 antibody - ab76716 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-Lnx1 antibody (ab76716) at 5 µg/ml + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-Lnx1 antibody - ab81257 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Lnx1 antibody [1H9] - ab140793 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H9
All lanes : Anti-Lnx1 antibody [1H9] (ab140793) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Lnx1 cDNALysates/proteins at 5 µg per lane.

Anti-Lnx1 antibody - C-terminal - ab174863 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Lnx1 antibody - C-terminal (ab174863) at 1/1000 dilution + HeLa total cell extract

Anti-LNX1 / LNX Antibody - LS-C140600 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LNX1 / LNX Antibody (aa274-285) - LS-C61761 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LNX1 / LNX Antibody - LS-C140589 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal

Anti-LNX1 / LNX Antibody - LS-C308776 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LNX1 / LNX Antibody (aa19-119) - LS-C308777 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LNX1 / LNX Antibody (aa431-480) - LS-C80569 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.

Anti-LNX1 / LNX Antibody (clone 1H9) - LS-C175459 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1H9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LNX1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LNX1.

Anti-LNX1 / LNX Antibody - LS-C334747 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U2OS cell using LNX1 antibody. Blue: DAPI for nuclear staining.

Lnx1 Antibody - NBP1-80518 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Lnx1 Antibody [NBP1-80518] - Transfected 293T cell lysate, concentration 1.25ug/ml.

Lnx1 Antibody - NBP1-81300 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Lnx1 Antibody (4E3) - H00084708-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E3
Sandwich ELISA: Lnx1 Antibody (4E3) [H00084708-M01] - Detection limit for recombinant GST tagged LNX1 is 0.3 ng/ml as a capture antibody.

Lnx1 Antibody - H00084708-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Lnx1 Antibody - H00084708-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Lnx1 Antibody - NB100-93412 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LNX1 antibody produced in rabbit - HPA002235 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LNX1: <B>Cat. No. HPA002235</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate tissue showing cytoplasmic and/or membranous staining of glandular cells.

Anti-LNX1 antibody produced in mouse - SAB1408122 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LNX1: <B>Cat. No. SAB1408122</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~69.5 kDa using LNX1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-LNX1 antibody produced in rabbit - AV43367 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: transfected 293T (<B>Cat. No. AV43367</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1.25 μg/mL in cell type transfected 293T
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