Gene Symbol | LNX1 |
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Entrez Gene | 84708 |
Alt Symbol | LNX, MPDZ, PDZRN2 |
Species | Human |
Gene Type | protein-coding |
Description | ligand of numb-protein X 1, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase LNX|PDZ domain-containing ring finger protein 2|multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX|numb-binding protein 1 |
Swissprots | Q8N4C2 Q9BY20 Q8TBB1 Q96MJ7 Q4W5K7 |
Accessions | AAY41000 EAX05450 EAX05451 Q8TBB1 AF237782 AAK15039 AK056823 BAB71291 AK294611 BAG57796 AY358326 AAQ88692 BC022983 AAH22983 BC034737 AAH34737 BC094772 DA154083 DA625539 DA854815 DA874715 DB159390 DQ893984 ABM84910 XM_005265785 XP_005265842 XM_005265786 XP_005265843 NM_001126328 NP_001119800 NM_032622 NP_116011 |
Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed in heart, placenta, kidney, pancreas and brain. {ECO:0000269|PubMed:11521506}. |
Human Lnx1 full length protein - ab164647 from Abcam
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Human Lnx1 protein fragment - ab164648 from Abcam
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LNX1 / LNX Antibody Blocking Peptide - LS-E15954 from LifeSpan Bioscience
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LNX1 / LNX Antibody Blocking Peptide - LS-E26347 from LifeSpan Bioscience
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Recombinant Human Lnx1 Protein - H00084708-Q01 from Novus Biologicals
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Recombinant Human Lnx1 Protein - H00084708-P01 from Novus Biologicals
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LNX1 Blocking Peptide - 33R-8514 from Fitzgerald
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LNX1 Peptide - AC21-1182-P from Abcore
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LNX1 - H00084708-P01-10 from Acris Antibodies
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LNX1 - H00084708-P01-25 from Acris Antibodies
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LNX1 - H00084708-Q01-10 from Acris Antibodies
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LNX1 - H00084708-Q01-25 from Acris Antibodies
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LNX1 Control Peptide - AP05289CP-N from Acris Antibodies
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LNX1 Peptide - 46-682P from ProSci
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LNX1 fusion protein - ag3823 from Proteintech Group
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LNX1 fusion protein - Ag14400 from Proteintech Group
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Recombinant Human E3 ubiquitin-protein ligase LNX(LNX1) - CSB-YP848393HU CSB-EP848393HU CSB-BP848393HU CSB-MP848393HU from Cusabio
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LNX1 Peptide (OEEG01155) - OEEG01155 from Aviva Systems Biology
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LNX1, Peptide - MBS396420 from MyBioSource
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LNX1, Peptide - MBS426434 from MyBioSource
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LNX1, Peptide - MBS658168 from MyBioSource
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Lnx1 Recombinant Protein Antigen - NBP1-81300PEP from Novus Biologicals
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LNX1 Antibody - SH-A13340 from Novatein Biosciences
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LNX1 Peptide, Human - M34GP08784H from Creative Peptides
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Lnx1 Recombinant Protein Antigen - NBP2-58844PEP from Novus Biologicals
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