| Gene Symbol |
LNX1
|
| Entrez Gene |
84708
|
| Alt Symbol |
LNX, MPDZ, PDZRN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ligand of numb-protein X 1, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase LNX|PDZ domain-containing ring finger protein 2|multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX|numb-binding protein 1
|
| Swissprots |
Q8N4C2 Q9BY20 Q8TBB1 Q96MJ7 Q4W5K7
|
| Accessions |
AAY41000 EAX05450 EAX05451 Q8TBB1 AF237782 AAK15039 AK056823 BAB71291 AK294611 BAG57796 AY358326 AAQ88692 BC022983 AAH22983 BC034737 AAH34737 BC094772 DA154083 DA625539 DA854815 DA874715 DB159390 DQ893984 ABM84910 XM_005265785 XP_005265842 XM_005265786 XP_005265843 NM_001126328 NP_001119800 NM_032622 NP_116011
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, placenta, kidney, pancreas and brain. {ECO:0000269|PubMed:11521506}.
|