| Gene Symbol | SUPV3L1 |
|---|---|
| Entrez Gene | 6832 |
| Alt Symbol | SUV3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of var1, 3-like 1 (S. cerevisiae) |
| Other Description | ATP-dependent RNA helicase SUPV3L1, mitochondrial|SUV3-like protein 1|suppressor of var1, 3-like 1(SUV3) |
| Swissprots | A8K301 Q8IYB8 O43630 |
| Accessions | EAW54314 EAW54315 Q8IYB8 AF042169 AAB97370 AK290416 BAF83105 AK299670 BAH13097 BC036112 AAH36112 BM675613 DC398467 DQ891004 ABM81930 DQ894183 ABM85109 XM_011540106 XP_011538408 XM_011540107 XP_011538409 NM_001301683 NP_001288612 NM_003171 NP_003162 |
| Function | Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255}. |
| Subcellular Location | Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid. |
| Tissue Specificity | Broadly expressed. {ECO:0000269|PubMed:10453991}. |
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), Human, ELISA Kit - E01A2003 from ARP American Research Products
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ATP dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7212323 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7237730 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7215992 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7216536 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7201699 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7235286 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7235293 from MyBioSource
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ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1), ELISA Kit - MBS7244022 from MyBioSource
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suppressor of var1, 3-like 1 (S. cerevisiae) , ELISA Kit - MBS9336946 from MyBioSource
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Human SUPV3L1 ELISA Kit - E004042 from Biobool
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