SUPV3L1

Gene Symbol SUPV3L1
Entrez Gene 6832
Alt Symbol SUV3
Species Human
Gene Type protein-coding
Description suppressor of var1, 3-like 1 (S. cerevisiae)
Other Description ATP-dependent RNA helicase SUPV3L1, mitochondrial|SUV3-like protein 1|suppressor of var1, 3-like 1(SUV3)
Swissprots A8K301 Q8IYB8 O43630
Accessions EAW54314 EAW54315 Q8IYB8 AF042169 AAB97370 AK290416 BAF83105 AK299670 BAH13097 BC036112 AAH36112 BM675613 DC398467 DQ891004 ABM81930 DQ894183 ABM85109 XM_011540106 XP_011538408 XM_011540107 XP_011538409 NM_001301683 NP_001288612 NM_003171 NP_003162
Function Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255}.
Subcellular Location Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Tissue Specificity Broadly expressed. {ECO:0000269|PubMed:10453991}.

SUV3 CRISPR/Cas9 KO Plasmid (h) - sc-409690 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 HDR Plasmid (h) - sc-409690-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 Double Nickase Plasmid (h) - sc-409690-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 Double Nickase Plasmid (h2) - sc-409690-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 CRISPR Activation Plasmid (h) - sc-409690-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 CRISPR Activation Plasmid (h2) - sc-409690-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 Lentiviral Activation Particles (h) - sc-409690-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 Lentiviral Activation Particles (h2) - sc-409690-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV3 siRNA (h) - sc-90749 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SUV3 shRNA Plasmid (h) - sc-90749-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SUV3 shRNA (h) Lentiviral Particles - sc-90749-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SUV3L1 RNAi - H00006832-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU073491 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20847 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20847 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SUPV3L1 siRNA (Human) - CRH4670 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUPV3L1 - MBS8238666 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SUPV3L1 (NM_003171.3) - SHH421064 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SUPV3L1(NM_003171.3) - SHL048360 from Creative biogene

Category siRNA
Species Reactivities Human

SUPV3L1 shRNA Plasmid (Human) - CHH4670 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SUPV3L1 miRNA 3'UTR clone - MiUTR1H-10073 from Creative biogene

Species Reactivities Human
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