| Gene Symbol |
FNTA
|
| Entrez Gene |
2339
|
| Alt Symbol |
FPTA, PGGT1A, PTAR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
farnesyltransferase, CAAX box, alpha
|
| Other Description |
FTase-alpha|GGTase-I-alpha|farnesyl-protein transferase alpha-subunit|protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha|protein prenyltransferase alpha subunit repeat containing 2|ras proteins prenyltransferase subunit alpha|type I protein geranyl-geranyltransferase alpha subunit
|
| Swissprots |
Q9UDC1 A6NJW0 Q53XJ9 P49354
|
| Accessions |
AAB26814 EAW63188 EAW63189 EAW63190 EAW63191 EAW63192 P49354 AB209689 BAD92926 AK091717 AK123002 BAG53844 AK292121 BAF84810 AL698961 BC017029 AAH17029 BC037295 BC084566 AAH84566 BI913631 BM686906 BT009854 AAP88856 BX648381 L00634 AAA35853 L10413 AAA86285 NM_002027 NP_002018 NR_033698 NM_001018676 NM_001018677
|
| Function |
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.
|
| Top Pathways |
Terpenoid backbone biosynthesis
|
![Western Blot: FNTA Overexpression Lysate (Adult Normal) [NBP2-08153] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FNTA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14599_FNTA%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08153-img0001.jpg)