FNTA
| Gene Symbol | FNTA |
|---|---|
| Entrez Gene | 2339 |
| Alt Symbol | FPTA, PGGT1A, PTAR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | farnesyltransferase, CAAX box, alpha |
| Other Description | FTase-alpha|GGTase-I-alpha|farnesyl-protein transferase alpha-subunit|protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha|protein prenyltransferase alpha subunit repeat containing 2|ras proteins prenyltransferase subunit alpha|type I protein geranyl-geranyltransferase alpha subunit |
| Swissprots | Q9UDC1 A6NJW0 Q53XJ9 P49354 |
| Accessions | AAB26814 EAW63188 EAW63189 EAW63190 EAW63191 EAW63192 P49354 AB209689 BAD92926 AK091717 AK123002 BAG53844 AK292121 BAF84810 AL698961 BC017029 AAH17029 BC037295 BC084566 AAH84566 BI913631 BM686906 BT009854 AAP88856 BX648381 L00634 AAA35853 L10413 AAA86285 NM_002027 NP_002018 NR_033698 NM_001018676 NM_001018677 |
| Function | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}. |
| Top Pathways | Terpenoid backbone biosynthesis |
FTα CRISPR/Cas9 KO Plasmid (h) - sc-403920 from Santa Cruz Biotechnology
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FTα HDR Plasmid (h) - sc-403920-HDR from Santa Cruz Biotechnology
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FTα Double Nickase Plasmid (h) - sc-403920-NIC from Santa Cruz Biotechnology
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FTα Double Nickase Plasmid (h2) - sc-403920-NIC-2 from Santa Cruz Biotechnology
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FTα CRISPR Activation Plasmid (h) - sc-403920-ACT from Santa Cruz Biotechnology
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FTα CRISPR Activation Plasmid (h2) - sc-403920-ACT-2 from Santa Cruz Biotechnology
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FTα Lentiviral Activation Particles (h) - sc-403920-LAC from Santa Cruz Biotechnology
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FTα Lentiviral Activation Particles (h2) - sc-403920-LAC-2 from Santa Cruz Biotechnology
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FTα siRNA (h) - sc-35420 from Santa Cruz Biotechnology
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FTα shRNA Plasmid (h) - sc-35420-SH from Santa Cruz Biotechnology
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FTα shRNA (h) Lentiviral Particles - sc-35420-V from Santa Cruz Biotechnology
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FNTA RNAi - H00002339-R03 from Novus Biologicals
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FNTA RNAi - H00002339-R01 from Novus Biologicals
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MISSION® esiRNA - EHU081721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8863 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8863 from Sigma-Aldrich
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FNTA siRNA (Human) - CRH1638 from Cohesion Biosciences
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FNTA RNAi - H00002339-R02 from Novus Biologicals
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FNTA - MBS8205042 from MyBioSource
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shRNA set against Human FNTA (NM_002027.2) - SHH296225 from Creative biogene
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shRNA set against Human FNTA(NM_002027.2) - SHH065135 from Creative biogene
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FNTA shRNA Plasmid (Human) - CHH1638 from Cohesion Biosciences
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FNTA miRNA 3'UTR clone - MiUTR1H-03799 from Creative biogene
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