| Gene Symbol |
MSL2
|
| Entrez Gene |
55167
|
| Alt Symbol |
MSL-2, MSL2L1, RNF184
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
male-specific lethal 2 homolog (Drosophila)
|
| Other Description |
E3 ubiquitin-protein ligase MSL2|MSL2-like 1|male-specific lethal 2-like 1|male-specific lethal-2 homolog 1|ring finger protein 184
|
| Swissprots |
Q9NVS4 G5E9I1 Q8NDB4 Q9HCI7 Q0D2P1 B4DYL4
|
| Accessions |
EAW79119 EAW79120 Q9HCI7 AB046805 BAB13411 AK001408 BAA91673 AK091956 AK292557 BAF85246 AK302491 BAG63776 AL834289 CAD38963 AW237818 AW271295 BC032719 AAH32719 BC093764 AAH93764 BC093790 AAH93790 DA674784 DC409643 XM_005247571 XP_005247628 XM_005247572 XP_005247629 XM_006713684 XP_006713747 XM_011512949 XP_011511251 NM_001145417 NP_001138889 NM_018133 NP_060603
|
| Function |
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269|PubMed:21726816}.
|