| Gene Symbol |
CUEDC2
|
| Entrez Gene |
79004
|
| Alt Symbol |
C10orf66, bA18I14.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CUE domain containing 2
|
| Other Description |
CUE domain-containing protein 2
|
| Swissprots |
D3DR88 Q9H467 Q9BWG8
|
| Accessions |
CAI93450 EAW49696 EAW49697 EAW49698 Q9H467 AB025425 BAB87809 AB232358 BAE19942 AF086406 BC000262 AAH00262 BF002772 BM756951 CX165866 NM_024040 NP_076945
|
| Function |
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. {ECO:0000269|PubMed:17347654, ECO:0000269|PubMed:21572428}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17347654}. Nucleus {ECO:0000269|PubMed:17347654}.
|
| Tissue Specificity |
Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
|
