Gene Symbol | CUEDC2 |
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Entrez Gene | 79004 |
Alt Symbol | C10orf66, bA18I14.5 |
Species | Human |
Gene Type | protein-coding |
Description | CUE domain containing 2 |
Other Description | CUE domain-containing protein 2 |
Swissprots | D3DR88 Q9H467 Q9BWG8 |
Accessions | CAI93450 EAW49696 EAW49697 EAW49698 Q9H467 AB025425 BAB87809 AB232358 BAE19942 AF086406 BC000262 AAH00262 BF002772 BM756951 CX165866 NM_024040 NP_076945 |
Function | Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. {ECO:0000269|PubMed:17347654, ECO:0000269|PubMed:21572428}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17347654}. Nucleus {ECO:0000269|PubMed:17347654}. |
Tissue Specificity | Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. |
Human-CUEDC2-cDNA-Clone - DC00111 from Abgent, a WuXi AppTec company
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CUEDC2 - MBS1275428 from MyBioSource
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Human CUEDC2 cDNA clone(NM_024040.2) - CDFG003998 from Creative Biomart
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Human CUEDC2 ORF Clone(NM_024040.2) - CDCR308647 from Creative Biomart
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Human CUEDC2 ORF Clone(NM_024040.2) - CDCR308648 from Creative Biomart
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Human CUEDC2 ORF Clone(NM_024040.2) - CDCR308649 from Creative Biomart
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Human CUEDC2 ORF clone(NM_024040.2) - CDCL183801 from Creative Biomart
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Human CUEDC2 ORF Clone(NM_024040.2) - CDCL160119 from Creative Biomart
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Human CUEDC2 ORF clone(NM_024040.2) - CDCL183801 from Creative biogene
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Human CUEDC2 ORF Clone (BC000262) - CDCS415640 from Creative biogene
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Human CUEDC2 cDNA Clone(NM_024040.2) - CDFG003998 from Creative biogene
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