Gene Symbol | CUEDC2 |
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Entrez Gene | 79004 |
Alt Symbol | C10orf66, bA18I14.5 |
Species | Human |
Gene Type | protein-coding |
Description | CUE domain containing 2 |
Other Description | CUE domain-containing protein 2 |
Swissprots | D3DR88 Q9H467 Q9BWG8 |
Accessions | CAI93450 EAW49696 EAW49697 EAW49698 Q9H467 AB025425 BAB87809 AB232358 BAE19942 AF086406 BC000262 AAH00262 BF002772 BM756951 CX165866 NM_024040 NP_076945 |
Function | Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. {ECO:0000269|PubMed:17347654, ECO:0000269|PubMed:21572428}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17347654}. Nucleus {ECO:0000269|PubMed:17347654}. |
Tissue Specificity | Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors. |
Human CUEDC2 full length protein - ab171602 from Abcam
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Human CUEDC2 protein fragment - ab132868 from Abcam
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CUEDC2 Antibody Blocking Peptide - LS-E22852 from LifeSpan Bioscience
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CUEDC2 Antibody Blocking Peptide - LS-E8475 from LifeSpan Bioscience
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CUEDC2 Antibody Blocking Peptide - LS-E30587 from LifeSpan Bioscience
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CUEDC2 Recombinant Protein - H00079004-P01 from Novus Biologicals
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Recombinant Human CUEDC2 Protein - NBP2-22968 from Novus Biologicals
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CUEDC2 Blocking Peptide - NBP1-77334PEP from Novus Biologicals
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CUEDC2-Antibody-C-term-Blocking-Peptide - BP6803b from Abgent, a WuXi AppTec company
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Human CUEDC2 protein - orb244983 from Biorbyt
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Human CUEDC2 protein - orb191344 from Biorbyt
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CUEDC2 protein (His tag) - 80R-3005 from Fitzgerald
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CUEDC2 (1-287, His-tag) - AR51123PU-N from Acris Antibodies
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CUEDC2 (1-287, His-tag) - AR51123PU-S from Acris Antibodies
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CUEDC2 - H00079004-P01-10 from Acris Antibodies
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CUEDC2 - H00079004-P01-25 from Acris Antibodies
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CUEDC2 Control Peptide - AP30262CP-N from Acris Antibodies
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CUEDC2, 1-287aa, Human, His tag, E.coli - 01-P2299 from ARP American Research Products
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CUEDC2 Peptide - 4839P from ProSci
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CUEDC2 fusion protein - ag13959 from Proteintech Group
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CUEDC2 fusion protein - Ag13847 from Proteintech Group
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CUEDC2, 1-287aa, Human, His tag, E.coli - GWB-ATG482 from Genway Biotech
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Recombinant Human CUEDC2, His-tagged - CUEDC2-2299H from Creative Biomart
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Recombinant Human CUE domain-containing protein 2(CUEDC2) - CSB-YP884464HU CSB-BP884464HU CSB-MP884464HU from Cusabio
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Recombinant human CUE domain-containing protein 2 - CSB-EP884464HU from Cusabio
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