PDE4B

Gene Symbol PDE4B
Entrez Gene 5142
Alt Symbol DPDE4, PDEIVB
Species Human
Gene Type protein-coding
Description phosphodiesterase 4B, cAMP-specific
Other Description cAMP-specific 3',5'-cyclic phosphodiesterase 4B|dunce-like phosphodiesterase E4|phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
Swissprots Q5TEK5 O15443 Q5TEK4 Q13945 A5YW33 Q5TEK6 Q07343
Accessions CAV28613 EAX06524 EAX06525 Q07343 AA206316 AA453531 AB209081 BAD92318 AK000989 AK127365 AK289969 BAF82658 AK290006 BAF82695 AK290206 BAF82895 AK294441 BAG57682 AW519027 BC036108 BC046161 BC071607 BC101480 AAI01481 BC105040 AAI05041 BF513098 CN268011 CR749667 CAH18458 DA103627 DA126733 DA311741 DA332822 DC399916 EF595686 ABQ85407 KJ534916 AHW56556 KJ534917 AHW56557 KJ535082 AHW56721 L12685 AAA35642 L12686 AAA35643 L20966 AAA03589 M97515 AAA36426 U85048 AAB96381 XM_005270923 XP_005270980 XM_005270924 XP_005270981 XM_005270925 XP_005270982 XM_006710680 XP_006710743 XM_011541565 XP_011539867 XM_011541566 XP_011539868 NM_001037339 NP_001032416 NM_001037340 NP_001032417 NM_001037341 NP_001032418 NM_001297440 NP_001284369 NM_001297441 NP_001284370 NM_001297442 NP_001284371 NM_002600 NP_002591
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}.
Tissue Specificity Expressed in brain, heart, lung and skeletal muscle.
Top Pathways Morphine addiction, cAMP signaling pathway, Purine metabolism

PDE4B (H-56) - sc-25812 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDE4B (H-56): sc-25812. Western blot analysis of PDE4B expression in mouse brain tissue extract.

PDE4B1 (N-15) - sc-25086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE4B2 (T-19) - sc-25087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE4B2 (T-19): sc-25087. Western blot analysis of PDE4B2 expression in Ramos whole cell lysate.

PDE4B3 (D-14) - sc-25088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE4B3 (D-14): sc-25088. Western blot analysis of PDE4B3 expression in PC-3 whole cell lysate.

Anti-PDE4B antibody - ab14611 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE4B antibody (ab14611) at 1/5000 dilutionLane 1 : Rat mesangial cells - whole cell lysateLane 2 : Rat mesangial cells - whole cell lysateLane 3 : Rat mesangial cells - whole cell lysateLysates/proteins at 5 µg per lane.SecondaryHRP conjugated goat anti-rabbit at 1/1000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PDE4B antibody - ab14612 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4B antibody - ab112014 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab112014, at 5µg/ml, staining PDE4B in formalin-fixed, paraffin-embedded Human Prostate tissue by Immunohistochemistry.

Anti-PDE4B antibody - ab77272 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-PDE4B antibody (ab77272) at 0.5 µg/ml + mouse brain lysate in RIPA buffer at 35 µg

Anti-PDE4B antibody - ab82712 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4B antibody [2B10] - ab119270 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B10
All lanes : Anti-PDE4B antibody [2B10] (ab119270) at 1/2000 dilutionLane 1 : HEK293T lysate transfected with pCMV6-ENTRY control cDNA for 48 hrsLane 2 : HEK293T lysate transfected with pCMV6-ENTRY PDE4B cDNA for 48 hrsLysates/proteins at 5 µg per lane.

Anti-PDE4B antibody [EPR11830] - ab170939 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11830
All lanes : Anti-PDE4B antibody [EPR11830] (ab170939) at 1/1000 dilutionLane 1 : Human fetal brain lysatesLane 2 : Human glioma lysatesLane 3 : A549 lysatesLysates/proteins at 10 µg per lane.

Anti-PDE4B3 antibody - ab14615 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE4B3 antibody (ab14615) at 1/350 dilutionLane 1 : Mock transfected Cos I cellsLane 2 : PDE4B3 transfected Cos I cells

Anti-PDE4B Antibody (clone 1D12) IHC-plus™ - LS-B11018 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D12
Anti-PDE4B antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11018 concentration 10 ug/ml.

Anti-PDE4B Antibody (aa467-516) IHC-plus™ - LS-B11957 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PDE4B Antibody (N-Terminus) - LS-C9586 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4B Antibody (N-Terminus) - LS-C90166 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4B Antibody (C-Terminus) - LS-C82359 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Anti-PDE4B Antibody (Internal) - LS-C145045 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4B Antibody (Internal) - LS-C153599 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4B Antibody (aa189-217, PE) - LS-C284509 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4B Antibody (aa189-217, Azide-free, HRP) - LS-C284510 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4D Antibody (His47) - LS-C176447 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of PDE4B/C/D (H47) pAb in paraffin-embedded human colon carcinoma tissue.

Anti-PDE4B Antibody (aa196-225) - LS-C323889 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4B Antibody (clone 2B10) - LS-C173255 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE4B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE4B.

Anti-PDE4B Antibody (clone 1B11) - LS-C337480 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE4B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE4B.
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