| Gene Symbol | PDE4B |
|---|---|
| Entrez Gene | 5142 |
| Alt Symbol | DPDE4, PDEIVB |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphodiesterase 4B, cAMP-specific |
| Other Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4B|dunce-like phosphodiesterase E4|phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) |
| Swissprots | Q5TEK5 O15443 Q5TEK4 Q13945 A5YW33 Q5TEK6 Q07343 |
| Accessions | CAV28613 EAX06524 EAX06525 Q07343 AA206316 AA453531 AB209081 BAD92318 AK000989 AK127365 AK289969 BAF82658 AK290006 BAF82695 AK290206 BAF82895 AK294441 BAG57682 AW519027 BC036108 BC046161 BC071607 BC101480 AAI01481 BC105040 AAI05041 BF513098 CN268011 CR749667 CAH18458 DA103627 DA126733 DA311741 DA332822 DC399916 EF595686 ABQ85407 KJ534916 AHW56556 KJ534917 AHW56557 KJ535082 AHW56721 L12685 AAA35642 L12686 AAA35643 L20966 AAA03589 M97515 AAA36426 U85048 AAB96381 XM_005270923 XP_005270980 XM_005270924 XP_005270981 XM_005270925 XP_005270982 XM_006710680 XP_006710743 XM_011541565 XP_011539867 XM_011541566 XP_011539868 NM_001037339 NP_001032416 NM_001037340 NP_001032417 NM_001037341 NP_001032418 NM_001297440 NP_001284369 NM_001297441 NP_001284370 NM_001297442 NP_001284371 NM_002600 NP_002591 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}. |
| Tissue Specificity | Expressed in brain, heart, lung and skeletal muscle. |
| Top Pathways | Morphine addiction, cAMP signaling pathway, Purine metabolism |
PDE4B CRISPR/Cas9 KO Plasmid (h) - sc-401961 from Santa Cruz Biotechnology
|
||||||||
PDE4B HDR Plasmid (h) - sc-401961-HDR from Santa Cruz Biotechnology
|
||||||||
PDE4B Double Nickase Plasmid (h) - sc-401961-NIC from Santa Cruz Biotechnology
|
||||||||
PDE4B Double Nickase Plasmid (h2) - sc-401961-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PDE4B CRISPR Activation Plasmid (h) - sc-401961-ACT from Santa Cruz Biotechnology
|
||||||||
PDE4B CRISPR Activation Plasmid (h2) - sc-401961-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PDE4B Lentiviral Activation Particles (h) - sc-401961-LAC from Santa Cruz Biotechnology
|
||||||||
PDE4B Lentiviral Activation Particles (h2) - sc-401961-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PDE4B2 siRNA (h) - sc-41599 from Santa Cruz Biotechnology
|
||||||||
PDE4B2 shRNA Plasmid (h) - sc-41599-SH from Santa Cruz Biotechnology
|
||||||||
PDE4B2 shRNA (h) Lentiviral Particles - sc-41599-V from Santa Cruz Biotechnology
|
||||||||
PDE4B3 siRNA (h) - sc-41600 from Santa Cruz Biotechnology
|
||||||||
PDE4B3 shRNA Plasmid (h) - sc-41600-SH from Santa Cruz Biotechnology
|
||||||||
PDE4B3 shRNA (h) Lentiviral Particles - sc-41600-V from Santa Cruz Biotechnology
|
||||||||
PDE4B siRNA (h) - sc-44003 from Santa Cruz Biotechnology
|
||||||||
PDE4B shRNA Plasmid (h) - sc-44003-SH from Santa Cruz Biotechnology
|
||||||||
PDE4B shRNA (h) Lentiviral Particles - sc-44003-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU134591 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN16537 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16537 from Sigma-Aldrich
|
||||||||
PDE4B siRNA (Human) - CRH3422 from Cohesion Biosciences
|
||||||||
shRNA set against Human PDE4B (NM_002600.3) - SHH372440 from Creative biogene
|
||||||||
shRNA set against Human PDE4B(NM_001037340.1) - SHR099996 from Creative biogene
|
||||||||
shRNA set against Human PDE4B(NM_002600.3) - SHR100014 from Creative biogene
|
||||||||
shRNA set against Human PDE4B(NM_001037341.1) - SHR100032 from Creative biogene
|