SUV420H2

Gene Symbol SUV420H2
Entrez Gene 84787
Alt Symbol KMT5C
Species Human
Gene Type protein-coding
Description suppressor of variegation 4-20 homolog 2 (Drosophila)
Other Description histone-lysine N-methyltransferase SUV420H2|lysine N-methyltransferase 5C|su(var)4-20 homolog 2|suv4-20h2
Swissprots Q9BRZ6 Q86Y97 Q8WZ10
Accessions EAW72364 EAW72365 EAW72366 Q86Y97 AF289582 AAL55766 AK304562 BAH14216 AK308586 AW248704 BC005842 AAH05842 BC019313 AAH19313 BC044889 AAH44889 XM_005259338 XP_005259395 XM_006723442 XP_006723505 XM_011527415 XP_011525717 XM_011527416 XP_011525718 NM_032701 NP_116090
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Top Pathways Lysine degradation

SUV420H2 (E-13) - sc-131076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SUV420H2 (H-95) - sc-366867 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SUV420H2 (H-95): sc-366867. Western blot analysis of SUV420H2 expression in A-431 (A) and A549 (B) whole cell lysates.

SUV420H2 (N-12) - sc-131078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SUV420H2 (N-12): sc-131078. Western blot analysis of SUV420H2 expression in MCF7 nuclear extract.

Anti-KMT5C/SUV4-20h2 antibody - ChIP Grade - ab91224 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KMT5C/SUV4-20h2 antibody - ChIP Grade (ab91224) at 1/50 dilution + Mouse stomach tissue lysate at 35 µg

Anti-SUV420H2 Antibody (aa2-279, Biotin) - LS-C301113 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SUV420H2 Antibody (aa2-279, FITC) - LS-C302135 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SUV420H2 Antibody (N-Terminus) - LS-C345487 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of SV422 Antibody with human 786-0 Whole Cell lysate.

Anti-SUV420H2 Antibody (aa67-98) - LS-C161630 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SUV4-20H2 Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The SUV4-20H2 antibody detected the SUV4-20H2 protein (arrow).

Anti-SUV420H2 Antibody (aa2-279) - LS-C296546 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SUV420H2.

Anti-SUV420H2 Antibody (Internal) - LS-C99227 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of SUV4-20H2 antibody in mouse stomach tissue lysates (35 ug/lane). SUV4-20H2 (arrow) was detected using the purified antibody.

SUV420H2 Antibody - NBP2-30524 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SUV420H2 Antibody [NBP2-30524] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.

ANTI-SUV4-20H2 (CENTER) antibody produced in rabbit - SAB1306143 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SUV4-20H2 (Center): <B>Cat. No. SAB1306143</B>: Western blot analysis of SUV4-20H2 Antibody (Center) in Mouse stomach tissue lysates (35 μg/lane).

Anti-SUV420H2 (252-265) antibody produced in rabbit - SAB1102703 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human SUV420H2 was separated on SDS-PAGE, blotted with Anti-SUV420H2 (252-265) (<B>Cat. No. SAB1102703</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500

Anti-SUV420H2 (71-85) antibody produced in rabbit - SAB1102702 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells was separated on SDS-PAGE, blotted with Anti-SUV420H2 (71-85) (<B>Cat. No. SAB1102702</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500<BR/>2. Antibody dilution 1:500 + SUV420H2 immunizing peptide (human, 71-85)

Anti-SUV420H2 antibody produced in rabbit - HPA052294 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SUV420H2: <B>Cat. No. HPA052294</B>: Immunohistochemical staining of human hippocampus shows strong cytoplasmic and nuclear positivity in neuronal cells.

SV422 Antibody - N-terminal region (ARP51248_P050) - ARP51248_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SUV4-20H2-Antibody-N-term - AP12073a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SUV4-20H2 Antibody (N-term) (Cat. #AP12073a) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SUV4-20H2 antibody detected the SUV4-20H2 protein (arrow).

SUV420H2 Antibody - middle region (OAAB03496) - OAAB03496 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SUV4-20H2-Antibody-Center - AP6511c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of SUV4-20H2 antibody (Center) (Cat.# AP6511c) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.

SUV4-20H2 Antibody - N-terminal region (OAAB08317) - OAAB08317 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SUV4-20H2 Antibody - abx032837 from Abbexa

Host Rabbit
Clonality Polyclonal

SUV420H2 / KMT5C (Center) antibody - AP17772PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of SUV4-20H2 antibody (Center) (AP17772PU-N) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.

SUV420H2 / KMT5C (N-term) antibody - AP54116PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SUV4-20H2 Antibody (N-term) (Cat. #AP54116PU-N) western blot analysis in mouse stomach tissue lysates (35 µg/lane). This demonstrates the SUV4-20H2 antibody detected the SUV4-20H2 protein (arrow).
SUV4-20H2 Antibody (N-term) (Cat# 102-11385) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SUV4-20H2 antibody detected the SUV4-20H2 protein (arrow).

SUV4-20H2 antibody (N-term) - STJ42067 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB14359
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