CCRN4L

Gene Symbol	CCRN4L
Entrez Gene	25819
Alt Symbol	CCR4L, Ccr4c, NOC
Species	Human
Gene Type	protein-coding
Description	CCR4 carbon catabolite repression 4-like (S. cerevisiae)
Other Description	CCR4 protein homolog|CCR4-like (carbon catabolite repression 4, S.cerevisiae)|carbon catabolite repression 4-like protein|circadian deadenylase NOC|nocturnin
Swissprots	Q9HD95 Q9UK39 D3DNY5 Q9HD94 Q9HD93 Q14D51
Accessions	AAG01387 EAX05129 EAX05130 EAX05131 Q9UK39 AF183961 AAD56548 AF199493 AAG01388 AF199494 AAG01389 BC021963 AAH21963 BC023512 AAH23512 BC077723 AAH77723 BC113494 AAI13495 BC113500 AAI13501 HY067201 NM_012118 NP_036250
Function	Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Tissue Specificity	Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue. {ECO:0000269|PubMed:22331129}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nocturnin protein fragment - ab161799 from Abcam Category Protein Source Wheat germ Species Human

CCRN4L / Nocturnin Antibody Blocking Peptide - LS-E8329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Nocturnin Protein - H00025819-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CCRN4L-Antibody-C-term-Blocking-Peptide - BP6611b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Nocturnin Blocking Peptide - abx161181 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

Nocturnin - H00025819-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Nocturnin - H00025819-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CCRN4L fusion protein - ag1172 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Carbon Catabolite Repression 4 Like Protein (CCRN4L) - RPP294Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Nocturnin Blocking Peptide - CBP3680 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken

Recombinant Carbon Catabolite Repression 4 Like Protein (CCRN4L) - RPP294Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Nocturnin(CCRN4L) - CSB-YP892448HU CSB-EP892448HU CSB-BP892448HU CSB-MP892448HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Nocturnin Recombinant Protein Antigen - NBP2-37939PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Nocturnin Recombinant Protein Antigen - NBP2-37856PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CCRN4L Peptide, Human - M34GP02682H from Creative Peptides Category Peptide Source Synthetic. Species Human

Nocturnin (CCRN4L), Recombinant Protein - MBS1411851 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,425.00, $1,425.00, $1,950.00, $1,950.00, $2,415.00, $2,415.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Nocturnin peptide - orb234555 from Biorbyt Category Peptide

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