| Gene Symbol |
HECW2
|
| Entrez Gene |
57520
|
| Alt Symbol |
NEDL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
|
| Other Description |
E3 ubiquitin-protein ligase HECW2|HECT, C2 and WW domain-containing protein 2|NEDD4-like E3 ubiquitin-protein ligase 2|NEDD4-related E3 ubiquitin ligase NEDL2
|
| Swissprots |
Q9NPS9 Q68DF8 Q17RT5 B8ZZB4 Q9P2P5
|
| Accessions |
EAW70123 Q9P2P5 AB037722 BAA92539 AL390186 CAB99103 BC117194 AAI17195 BC117198 AAI17199 CR749424 CAH18262 XM_006712646 XP_006712709 XM_006712648 XP_006712711 NM_001304840 NP_001291769 NM_020760 NP_065811
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. {ECO:0000269|PubMed:12890487}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in adult brain, lung and heart. {ECO:0000269|PubMed:12890487}.
|
![Western Blot: NEDL2 Overexpression Lysate (Adult Normal) [NBP2-06610] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NEDL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8247_NEDL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06610-img0001.jpg)