| Gene Symbol |
HECW2
|
| Entrez Gene |
57520
|
| Alt Symbol |
NEDL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
|
| Other Description |
E3 ubiquitin-protein ligase HECW2|HECT, C2 and WW domain-containing protein 2|NEDD4-like E3 ubiquitin-protein ligase 2|NEDD4-related E3 ubiquitin ligase NEDL2
|
| Swissprots |
Q9NPS9 Q68DF8 Q17RT5 B8ZZB4 Q9P2P5
|
| Accessions |
EAW70123 Q9P2P5 AB037722 BAA92539 AL390186 CAB99103 BC117194 AAI17195 BC117198 AAI17199 CR749424 CAH18262 XM_006712646 XP_006712709 XM_006712648 XP_006712711 NM_001304840 NP_001291769 NM_020760 NP_065811
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. {ECO:0000269|PubMed:12890487}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in adult brain, lung and heart. {ECO:0000269|PubMed:12890487}.
|