Gene Symbol | HECW2 |
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Entrez Gene | 57520 |
Alt Symbol | NEDL2 |
Species | Human |
Gene Type | protein-coding |
Description | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 |
Other Description | E3 ubiquitin-protein ligase HECW2|HECT, C2 and WW domain-containing protein 2|NEDD4-like E3 ubiquitin-protein ligase 2|NEDD4-related E3 ubiquitin ligase NEDL2 |
Swissprots | Q9NPS9 Q68DF8 Q17RT5 B8ZZB4 Q9P2P5 |
Accessions | EAW70123 Q9P2P5 AB037722 BAA92539 AL390186 CAB99103 BC117194 AAI17195 BC117198 AAI17199 CR749424 CAH18262 XM_006712646 XP_006712709 XM_006712648 XP_006712711 NM_001304840 NP_001291769 NM_020760 NP_065811 |
Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. {ECO:0000269|PubMed:12890487}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in adult brain, lung and heart. {ECO:0000269|PubMed:12890487}. |
NEDL2 CRISPR/Cas9 KO Plasmid (h) - sc-410607 from Santa Cruz Biotechnology
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NEDL2 HDR Plasmid (h) - sc-410607-HDR from Santa Cruz Biotechnology
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NEDL2 Double Nickase Plasmid (h) - sc-410607-NIC from Santa Cruz Biotechnology
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NEDL2 Double Nickase Plasmid (h2) - sc-410607-NIC-2 from Santa Cruz Biotechnology
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NEDL2 CRISPR Activation Plasmid (h) - sc-410607-ACT from Santa Cruz Biotechnology
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NEDL2 CRISPR Activation Plasmid (h2) - sc-410607-ACT-2 from Santa Cruz Biotechnology
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NEDL2 Lentiviral Activation Particles (h) - sc-410607-LAC from Santa Cruz Biotechnology
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NEDL2 Lentiviral Activation Particles (h2) - sc-410607-LAC-2 from Santa Cruz Biotechnology
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NEDL2 siRNA (h) - sc-95007 from Santa Cruz Biotechnology
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NEDL2 shRNA Plasmid (h) - sc-95007-SH from Santa Cruz Biotechnology
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NEDL2 shRNA (h) Lentiviral Particles - sc-95007-V from Santa Cruz Biotechnology
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NEDL2 RNAi - H00057520-R01 from Novus Biologicals
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MISSION® esiRNA - EHU003591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9963 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9963 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11018 from Sigma-Aldrich
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HECW2 siRNA (Human) - CRJ1503 from Cohesion Biosciences
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HECW2 - MBS8217853 from MyBioSource
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shRNA set against Human HECW2 (NM_020760.1) - SHH311409 from Creative biogene
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HECW2 shRNA Plasmid (Human) - CHJ1503 from Cohesion Biosciences
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HECW2 miRNA 3'UTR clone - MiUTR1H-04452 from Creative biogene
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