CSF1

Gene Symbol	CSF1
Entrez Gene	1435
Alt Symbol	CSF-1, MCSF
Species	Human
Gene Type	protein-coding
Description	colony stimulating factor 1 (macrophage)
Other Description	lanimostim|macrophage colony-stimulating factor 1
Swissprots	Q9UQR8 Q5VVF3 Q14806 Q14086 A8K6J5 Q13130 Q5VVF4 P09603
Accessions	AAB59527 CAA29479 CAJ32234 CAJ32235 CAJ32236 CBX54357 CBX55878 CBX55879 CBX55880 CCA65433 CCA65434 CCA65435 EAW56416 EAW56417 EAW56418 EAW56419 EAW56420 EAW56421 P09603 AB208952 BAD92189 AI758702 AK291660 BAF84349 AK300401 BAG62132 AK311440 BC021117 AAH21117 DA414355 DB287787 JF803735 AEF12310 M27087 AAA59573 M37435 AAA52117 M64592 AAA59572 M76453 AAA52120 U22386 AAA64849 X05825 CAA29265 NM_000757 NP_000748 NM_172210 NP_757349 NM_172211 NP_757350 NM_172212 NP_757351
Function	Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Osteoclast differentiation, Rheumatoid arthritis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MCSF full length protein - ab192170 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human MCSF protein fragment - ab62015 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source E. coli Species Human

Active human MCSF protein fragment - ab73751 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Human

Active MCSF full length protein - ab9694 from Abcam Category Protein Prices $110.00, $257.00 Sizes 2 µg, 10 µg Source E. coli

Active mouse MCSF protein fragment - ab129146 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Mouse

Active rat MCSF protein fragment - ab125758 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source HEK 293 cells Species Rat

Human MCSF full length protein - ab193882 from Abcam Category Protein Source Mammalian Species Human

Human MCSF protein fragment - ab151808 from Abcam Category Protein Source HEK 293 cells Species Human

Human MCSF protein fragment - ab193887 from Abcam Category Protein Source Mammalian Species Human

Human MCSF protein fragment - ab90707 from Abcam Category Protein Source E. coli Species Human

Mouse MCSF protein fragment - ab169716 from Abcam Category Protein Source Yeast Species Mouse

Mouse MCSF protein fragment - ab51920 from Abcam Category Protein Source E. coli Species Mouse

Rat MCSF protein fragment - ab56288 from Abcam Category Protein Source E. coli Species Rat

CSF1 / MCSF Antibody Blocking Peptide - LS-E16285 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSF1 / MCSF Antibody Blocking Peptide - LS-E16286 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSF1 / MCSF Antibody Blocking Peptide - LS-E8439 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human M-CSF Protein - NBP2-34975 from Novus Biologicals Category Protein Prices $69.00, $169.00, $769.00, $3,829.00 Sizes 2 µg, 10 µg, 100 µg, 1 mg Source E. coli Species Human

M-CSF Protein - NBP1-43166 from Novus Biologicals Category Protein Prices $289.00 Sizes 25 µg

M-CSF Recombinant Protein - H00001435-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human M-CSF Protein - H00001435-Q01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human M-CSF Protein - NBP1-30174 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

M-CSF Recombinant Protein - P3649 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

M-CSF Recombinant Protein - P4421 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

M-CSF Protein - NBP1-99814 from Novus Biologicals Category Protein Prices $299.00 Sizes 10 µg Species Human

M-CSF Protein - NBP1-99948 from Novus Biologicals Category Protein Species Human

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