CSF1
| Gene Symbol | CSF1 |
|---|---|
| Entrez Gene | 1435 |
| Alt Symbol | CSF-1, MCSF |
| Species | Human |
| Gene Type | protein-coding |
| Description | colony stimulating factor 1 (macrophage) |
| Other Description | lanimostim|macrophage colony-stimulating factor 1 |
| Swissprots | Q9UQR8 Q5VVF3 Q14806 Q14086 A8K6J5 Q13130 Q5VVF4 P09603 |
| Accessions | AAB59527 CAA29479 CAJ32234 CAJ32235 CAJ32236 CBX54357 CBX55878 CBX55879 CBX55880 CCA65433 CCA65434 CCA65435 EAW56416 EAW56417 EAW56418 EAW56419 EAW56420 EAW56421 P09603 AB208952 BAD92189 AI758702 AK291660 BAF84349 AK300401 BAG62132 AK311440 BC021117 AAH21117 DA414355 DB287787 JF803735 AEF12310 M27087 AAA59573 M37435 AAA52117 M64592 AAA59572 M76453 AAA52120 U22386 AAA64849 X05825 CAA29265 NM_000757 NP_000748 NM_172210 NP_757349 NM_172211 NP_757350 NM_172212 NP_757351 |
| Function | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Osteoclast differentiation, Rheumatoid arthritis, PI3K-Akt signaling pathway |
M-CSF CRISPR/Cas9 KO Plasmid (h) - sc-401339 from Santa Cruz Biotechnology
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M-CSF HDR Plasmid (h) - sc-401339-HDR from Santa Cruz Biotechnology
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M-CSF Double Nickase Plasmid (h) - sc-401339-NIC from Santa Cruz Biotechnology
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M-CSF Double Nickase Plasmid (h2) - sc-401339-NIC-2 from Santa Cruz Biotechnology
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M-CSF CRISPR Activation Plasmid (h) - sc-401339-ACT from Santa Cruz Biotechnology
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M-CSF CRISPR Activation Plasmid (h2) - sc-401339-ACT-2 from Santa Cruz Biotechnology
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M-CSF Lentiviral Activation Particles (h) - sc-401339-LAC from Santa Cruz Biotechnology
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M-CSF Lentiviral Activation Particles (h2) - sc-401339-LAC-2 from Santa Cruz Biotechnology
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M-CSF siRNA (h) - sc-39393 from Santa Cruz Biotechnology
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M-CSF shRNA Plasmid (h) - sc-39393-SH from Santa Cruz Biotechnology
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M-CSF shRNA (h) Lentiviral Particles - sc-39393-V from Santa Cruz Biotechnology
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M-CSF RNAi - H00001435-R04 from Novus Biologicals
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M-CSF RNAi - H00001435-R01 from Novus Biologicals
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M-CSF RNAi - H00001435-R02 from Novus Biologicals
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M-CSF RNAi - H00001435-R03 from Novus Biologicals
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MISSION® esiRNA - EHU084211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1797 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1797 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07059 from Sigma-Aldrich
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CSF1 siRNA (Human) - CRH1009 from Cohesion Biosciences
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CSF1 - MBS8217045 from MyBioSource
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shRNA set against Human CSF1 (NM_000757.5) - SHH270217 from Creative biogene
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shRNA set against Human CSF1(NM_172210.2) - SHG202285 from Creative biogene
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Human CSF1 siRNA - orb261511 from Biorbyt
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CSF1 shRNA Plasmid (Human) - CHH1009 from Cohesion Biosciences
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