| Gene Symbol | RNLS |
|---|---|
| Entrez Gene | 55328 |
| Alt Symbol | C10orf59, RENALASE |
| Species | Human |
| Gene Type | protein-coding |
| Description | renalase, FAD-dependent amine oxidase |
| Other Description | MAO-C|alpha-NAD(P)H oxidase/anomerase|monoamine oxidase-C|renalase |
| Swissprots | Q5VYX0 Q9NUP8 Q9BS33 |
| Accessions | AEW43431 AEW43432 EAW50167 EAW50168 EAW50169 EAW50170 EAW50171 Q5VYX0 AA854849 AK002080 BAA92073 AK296262 BAG58975 BC005364 AAH05364 BM978857 BP332262 BX648154 HQ448189 ADQ32670 XM_005269946 XP_005270003 XM_005269947 XP_005270004 XM_005269948 XP_005270005 XM_005269949 XP_005270006 XM_005269950 XP_005270007 XM_011539924 XP_011538226 XM_011539925 XP_011538227 XM_011539926 XP_011538228 XM_011539927 XP_011538229 NM_001031709 NP_001026879 NM_018363 NP_060833 |
| Function | Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:15841207}. |
| Tissue Specificity | Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. {ECO:0000269|PubMed:15841207}. |