RNLS

Gene Symbol	RNLS
Entrez Gene	55328
Alt Symbol	C10orf59, RENALASE
Species	Human
Gene Type	protein-coding
Description	renalase, FAD-dependent amine oxidase
Other Description	MAO-C|alpha-NAD(P)H oxidase/anomerase|monoamine oxidase-C|renalase
Swissprots	Q5VYX0 Q9NUP8 Q9BS33
Accessions	AEW43431 AEW43432 EAW50167 EAW50168 EAW50169 EAW50170 EAW50171 Q5VYX0 AA854849 AK002080 BAA92073 AK296262 BAG58975 BC005364 AAH05364 BM978857 BP332262 BX648154 HQ448189 ADQ32670 XM_005269946 XP_005270003 XM_005269947 XP_005270004 XM_005269948 XP_005270005 XM_005269949 XP_005270006 XM_005269950 XP_005270007 XM_011539924 XP_011538226 XM_011539925 XP_011538227 XM_011539926 XP_011538228 XM_011539927 XP_011538229 NM_001031709 NP_001026879 NM_018363 NP_060833
Function	Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068}.
Subcellular Location	Secreted {ECO:0000269|PubMed:15841207}.
Tissue Specificity	Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. {ECO:0000269|PubMed:15841207}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Renalase full length protein - ab132381 from Abcam Category Protein Source Wheat germ Species Human

Human Renalase full length protein - ab134535 from Abcam Category Protein Source E. coli Species Human

Renalase peptide (224-234) - ab45730 from Abcam Category Peptide Species Human

RNLS / Renalase Antibody Blocking Peptide - LS-E21811 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNLS / Renalase Antibody Blocking Peptide - LS-E25873 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNLS / Renalase Antibody Blocking Peptide - LS-E26370 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Renalase Recombinant Protein - H00055328-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Renalase Protein - NBP2-23407 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

C10orf59-Antibody-Center-Blocking-Peptide - BP8552c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Renalase (aa 134 to 147) blocking peptide - GTX88868-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Renalase (aa 224 to 233) blocking peptide - GTX89570-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human RNLS protein - orb169203 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

RNLS protein (His tag) - 80R-2484 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human Renalase Protein - abx068861 from Abbexa Category Protein Source E.coli Species Human

Renalase Peptide - AC21-0703-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Renalase Peptide - AC21-1205-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Renalase (18-342, His-tag) - AR50556PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Renalase (18-342, His-tag) - AR50556PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Renalase - H00055328-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Renalase - H00055328-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Renalase (RNLS), Human - 20-8590 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

Renalase (RNLS), Human - 20-8591 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

RNLS, 18-342aa, Human, His tag, E.coli - 01-P1732 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Renalase Peptide - 46-278P from ProSci Category Peptide Species Human, Mouse

Renalase Peptide - 46-279P from ProSci Category Peptide Species Mouse, Rat

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