RNLS

Gene Symbol RNLS
Entrez Gene 55328
Alt Symbol C10orf59, RENALASE
Species Human
Gene Type protein-coding
Description renalase, FAD-dependent amine oxidase
Other Description MAO-C|alpha-NAD(P)H oxidase/anomerase|monoamine oxidase-C|renalase
Swissprots Q5VYX0 Q9NUP8 Q9BS33
Accessions AEW43431 AEW43432 EAW50167 EAW50168 EAW50169 EAW50170 EAW50171 Q5VYX0 AA854849 AK002080 BAA92073 AK296262 BAG58975 BC005364 AAH05364 BM978857 BP332262 BX648154 HQ448189 ADQ32670 XM_005269946 XP_005270003 XM_005269947 XP_005270004 XM_005269948 XP_005270005 XM_005269949 XP_005270006 XM_005269950 XP_005270007 XM_011539924 XP_011538226 XM_011539925 XP_011538227 XM_011539926 XP_011538228 XM_011539927 XP_011538229 NM_001031709 NP_001026879 NM_018363 NP_060833
Function Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068}.
Subcellular Location Secreted {ECO:0000269|PubMed:15841207}.
Tissue Specificity Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. {ECO:0000269|PubMed:15841207}.

Renalase CRISPR/Cas9 KO Plasmid (h) - sc-410007 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase HDR Plasmid (h) - sc-410007-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase Double Nickase Plasmid (h) - sc-410007-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase Double Nickase Plasmid (h2) - sc-410007-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase CRISPR Activation Plasmid (h) - sc-410007-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase CRISPR Activation Plasmid (h2) - sc-410007-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase Lentiviral Activation Particles (h) - sc-410007-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase Lentiviral Activation Particles (h2) - sc-410007-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Renalase siRNA (h) - sc-76384 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Renalase shRNA Plasmid (h) - sc-76384-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Renalase shRNA (h) Lentiviral Particles - sc-76384-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU066641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18449 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18449 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08028 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08028

RNLS siRNA (Human) - CRJ0660 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNLS - MBS8208782 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNLS (NM_018363.3) - SHH397489 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNLS siRNA - orb271161 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNLS shRNA Plasmid (Human) - CHJ0660 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNLS miRNA 3'UTR clone - MiUTR3H-10557 from Creative biogene

Species Reactivities Human

RNLS miRNA 3'UTR clone - MiUTR3H-10558 from Creative biogene

Species Reactivities Human
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