HTR2A

Gene Symbol HTR2A
Entrez Gene 3356
Alt Symbol 5-HT2A, HTR2
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Other Description 5-HT-2A|5-HT2 receptor|5-hydroxytryptamine receptor 2A|serotonin 5-HT-2A receptor
Swissprots F5GWE8 B4DZ79 P28223 Q5T8C0 B2RAC5
Accessions AAB22791 AAB24166 AAD14995 ACE96348 ACE96353 ACE96358 AGB76027 BAA90433 EAX08770 P28223 A23337 CAA01675 AA418604 AF498982 AAM21129 AK302787 BAG63991 AK314132 BAG36822 BC069356 AAH69356 BC069576 AAH69576 BC074848 AAH74848 BC074849 AAH74849 BC096839 AAH96839 BX647777 DA233936 DA247468 DC321645 DN990785 M86841 AAA58354 S71229 AAB31320 X57830 CAA40963 NM_000621 NP_000612 NM_001165947 NP_001159419
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle con
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Membrane, caveola {ECO:0000250}. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.
Tissue Specificity Detected in brain cortex (at protein level). Detected in blood platelets. {ECO:0000269|PubMed:18297054}.
Top Pathways Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

SR-2A (A-4) - sc-166775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SR-2A (A-4): sc-166775. Western blot analysis of SR-2A expression in HEK293 whole cell lysate.

SR-2A (D-20) - sc-32538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-2A (D-20): sc-32538. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells, glial cells and endothelial cells.

SR-2A (H-18) - sc-15074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-2A (A-15) - sc-15073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-2A (A-15): sc-15073. Western blot analysis of mouse recombinant SR-2A fusion protein.

SR-2A (L-20) - sc-32537 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-2A (L-20): sc-32537. Western blot analysis of human recombinant SR-2A fusion protein.

SR-2A (H-75) - sc-50396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-5HT2A Receptor antibody - ab66049 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab66049 at 1/100 dilution staining 5HT2A Receptor in Mouse frontal cortical neuron cultures (p1 pups, day 4 culture, for 48hrs) by Immunohistochemistry, Paraformaldehyde-fixed tissue.

Anti-5HT2A Receptor antibody - ab102703 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-5HT2A Receptor antibody - ab85496 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-5HT2A Receptor antibody (ab85496) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-5HT2A Receptor antibody - C-terminal - ab140524 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human placenta tissue labelling 5HT2A Receptor with ab140524 at 10 µg/ml.

Anti-HTR2A / 5-HT2A Receptor Antibody (C-Terminus) IHC-plus™ - LS-A1109 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT2A Receptor antibody LS-A1109 IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR2A / 5-HT2A Receptor Antibody (aa346-360) - LS-C87268 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody (aa296-309) - LS-C155072 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody (aa418-432, Magnetic beads) - LS-C172271 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody (aa418-432, Sepharose) - LS-C172272 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody (aa418-432) - LS-C172270 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody (aa422-471) - LS-C291279 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody - LS-C314051 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2A / 5-HT2A Receptor Antibody (N-Terminus) - LS-C102841 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HTR2A / 5-HT2A antibody LS-C102841 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-HTR2A / 5-HT2A Receptor Antibody - LS-C203034 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal
Western blot of tissue lysates, using 5HT2A Receptor Antibody, pAb, Rabbit (1 ug/ml). The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG. Predicted Size: 52 kD. Observed Size: 52 kD.

Anti-HTR2A / 5-HT2A Receptor Antibody (N-Terminus) IHC-plus™ - LS-A1106 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT2A Receptor antibody LS-A1106 IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after antigen retrieval with Proteinase K.

5-HT2A Antibody - NBP1-90318 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: 5-HT2A Antibody [NBP1-90318] - Staining of human lateral ventricle shows distinct positivity.

5-HT2A Antibody - NBP1-46542 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

5-HT2A Antibody - NBP2-26091 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

5-HT2A Antibody - NBP1-20933 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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