HTR2A

Gene Symbol HTR2A
Entrez Gene 3356
Alt Symbol 5-HT2A, HTR2
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Other Description 5-HT-2A|5-HT2 receptor|5-hydroxytryptamine receptor 2A|serotonin 5-HT-2A receptor
Swissprots F5GWE8 B4DZ79 P28223 Q5T8C0 B2RAC5
Accessions AAB22791 AAB24166 AAD14995 ACE96348 ACE96353 ACE96358 AGB76027 BAA90433 EAX08770 P28223 A23337 CAA01675 AA418604 AF498982 AAM21129 AK302787 BAG63991 AK314132 BAG36822 BC069356 AAH69356 BC069576 AAH69576 BC074848 AAH74848 BC074849 AAH74849 BC096839 AAH96839 BX647777 DA233936 DA247468 DC321645 DN990785 M86841 AAA58354 S71229 AAB31320 X57830 CAA40963 NM_000621 NP_000612 NM_001165947 NP_001159419
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle con
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Membrane, caveola {ECO:0000250}. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.
Tissue Specificity Detected in brain cortex (at protein level). Detected in blood platelets. {ECO:0000269|PubMed:18297054}.
Top Pathways Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

SR-2A CRISPR/Cas9 KO Plasmid (h) - sc-401532 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A HDR Plasmid (h) - sc-401532-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A Double Nickase Plasmid (h) - sc-401532-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A Double Nickase Plasmid (h2) - sc-401532-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A CRISPR Activation Plasmid (h) - sc-401532-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A CRISPR Activation Plasmid (h2) - sc-401532-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A Lentiviral Activation Particles (h) - sc-401532-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A Lentiviral Activation Particles (h2) - sc-401532-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2A siRNA (h) - sc-42231 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SR-2A shRNA Plasmid (h) - sc-42231-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SR-2A shRNA (h) Lentiviral Particles - sc-42231-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

5-HT2A RNAi - H00003356-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1766 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1766 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HTR2A siRNA (Human) - CRH2286 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HTR2A - MBS8212869 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HTR2A (NM_000621.4) - SHH315913 from Creative biogene

Category siRNA
Species Reactivities Human

HTR2A shRNA Plasmid (Human) - CHH2286 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HTR2A miRNA 3'UTR clone - MiUTR3H-02090 from Creative biogene

Species Reactivities Human

HTR2A miRNA 3'UTR clone - MiUTR3H-02091 from Creative biogene

Species Reactivities Human
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