HTR2A

Gene Symbol	HTR2A
Entrez Gene	3356
Alt Symbol	5-HT2A, HTR2
Species	Human
Gene Type	protein-coding
Description	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Other Description	5-HT-2A|5-HT2 receptor|5-hydroxytryptamine receptor 2A|serotonin 5-HT-2A receptor
Swissprots	F5GWE8 B4DZ79 P28223 Q5T8C0 B2RAC5
Accessions	AAB22791 AAB24166 AAD14995 ACE96348 ACE96353 ACE96358 AGB76027 BAA90433 EAX08770 P28223 A23337 CAA01675 AA418604 AF498982 AAM21129 AK302787 BAG63991 AK314132 BAG36822 BC069356 AAH69356 BC069576 AAH69576 BC074848 AAH74848 BC074849 AAH74849 BC096839 AAH96839 BX647777 DA233936 DA247468 DC321645 DN990785 M86841 AAA58354 S71229 AAB31320 X57830 CAA40963 NM_000621 NP_000612 NM_001165947 NP_001159419
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle con
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Membrane, caveola {ECO:0000250}. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.
Tissue Specificity	Detected in brain cortex (at protein level). Detected in blood platelets. {ECO:0000269|PubMed:18297054}.
Top Pathways	Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

5HT2A Receptor peptide - ab16195 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

HTR2A / 5-HT2A Receptor Blocking Peptide - LS-E5381 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2A / 5-HT2A Receptor Antibody Blocking Peptide - LS-E10702 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2A / 5-HT2A Receptor Antibody Blocking Peptide - LS-E28136 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR2A / 5-HT2A Receptor Antibody Blocking Peptide - LS-E28137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR2A / 5-HT2A Receptor Antibody Blocking Peptide - LS-E26707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2A / 5-HT2A Receptor Antibody Blocking Peptide - LS-E27979 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2A-Antibody-Center-Blocking-Peptide - BP17879c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

5-HT2A receptor blocking peptide - GTX88769-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

HTR2A Blocking Peptide - 33R-1998 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

5-HT2A Blocking Peptide - abx062758 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Pig

5HT2A receptor Peptide - AC21-1546-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

5HT2A receptor Peptide - AC21-2741-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Serotonin receptor 2A (HTR2A) Control Peptide - 24333 from Acris Antibodies Category Peptide Prices $135.00 Sizes 25 µg

HTR2A Peptide - 43-106P from ProSci Category Peptide

HTR2A Peptide - 46-857P from ProSci Category Peptide

HTR2A fusion protein - Ag24447 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

HTR2A fusion protein - ag12407 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HTR2A fusion protein - ag12401 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HTR2A, GST-tagged - HTR2A-1872H from Creative Biomart Category Protein Source E. coli.

Recombinant Human HTR2A, His-tagged - HTR2A-1729H from Creative Biomart Category Protein Source E. coli.

Recombinant Human HTR2A - HTR2A-362H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant 5-Hydroxytryptamine Receptor 2A (HTR2A) - RPD486Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

ChemiSCREEN™ Human 5-HT 2A Serotonin Receptor Membrane Preparation - HTS082M from EMD Millipore Species Human

5-HT2A Blocking Peptide - CBP1564 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey, Pig

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