| Gene Symbol |
HTR2A
|
| Entrez Gene |
3356
|
| Alt Symbol |
5-HT2A, HTR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
|
| Other Description |
5-HT-2A|5-HT2 receptor|5-hydroxytryptamine receptor 2A|serotonin 5-HT-2A receptor
|
| Swissprots |
F5GWE8 B4DZ79 P28223 Q5T8C0 B2RAC5
|
| Accessions |
AAB22791 AAB24166 AAD14995 ACE96348 ACE96353 ACE96358 AGB76027 BAA90433 EAX08770 P28223 A23337 CAA01675 AA418604 AF498982 AAM21129 AK302787 BAG63991 AK314132 BAG36822 BC069356 AAH69356 BC069576 AAH69576 BC074848 AAH74848 BC074849 AAH74849 BC096839 AAH96839 BX647777 DA233936 DA247468 DC321645 DN990785 M86841 AAA58354 S71229 AAB31320 X57830 CAA40963 NM_000621 NP_000612 NM_001165947 NP_001159419
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle con
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Membrane, caveola {ECO:0000250}. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain cortex (at protein level). Detected in blood platelets. {ECO:0000269|PubMed:18297054}.
|
| Top Pathways |
Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|