| Gene Symbol |
UBE2T
|
| Entrez Gene |
29089
|
| Alt Symbol |
HSPC150, PIG50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2T
|
| Other Description |
HSPC150 protein similar to ubiquitin-conjugating enzyme|cell proliferation-inducing gene 50 protein|ubiquitin carrier protein T|ubiquitin conjugating enzyme|ubiquitin-conjugating enzyme E2 T|ubiquitin-conjugating enzyme E2T (putative)|ubiquitin-protein ligase T
|
| Swissprots |
Q2TU36 Q9NPD8
|
| Accessions |
CAI84529 EAW91411 EAW91412 EAW91413 EAW91414 EAW91415 Q9NPD8 AB032931 BAA93711 AF160215 AAF67016 AF161499 AAF29114 AK000504 BAA91211 AY542309 AAT08178 BC004152 AAH04152 BC019284 AAH19284 BG776416 DQ892729 ABM83655 DQ895975 ABM86901 NM_014176 NP_054895
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19887602}. Note=Accumulates to chromatin.
|
| Top Pathways |
Fanconi anemia pathway
|