UBE2T

Gene Symbol	UBE2T
Entrez Gene	29089
Alt Symbol	HSPC150, PIG50
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2T
Other Description	HSPC150 protein similar to ubiquitin-conjugating enzyme|cell proliferation-inducing gene 50 protein|ubiquitin carrier protein T|ubiquitin conjugating enzyme|ubiquitin-conjugating enzyme E2 T|ubiquitin-conjugating enzyme E2T (putative)|ubiquitin-protein ligase T
Swissprots	Q2TU36 Q9NPD8
Accessions	CAI84529 EAW91411 EAW91412 EAW91413 EAW91414 EAW91415 Q9NPD8 AB032931 BAA93711 AF160215 AAF67016 AF161499 AAF29114 AK000504 BAA91211 AY542309 AAT08178 BC004152 AAH04152 BC019284 AAH19284 BG776416 DQ892729 ABM83655 DQ895975 ABM86901 NM_014176 NP_054895
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19887602}. Note=Accumulates to chromatin.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HSPC150 full length protein - ab95318 from Abcam Category Protein Source E. coli Species Human

Human HSPC150 full length protein - ab117477 from Abcam Category Protein Source E. coli Species Human

Human HSPC150 peptide - ab23018 from Abcam Category Peptide Species Human

UBE2T / HSPC150 Antibody Blocking Peptide - LS-E4982 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2T / HSPC150 Antibody Blocking Peptide - LS-E25475 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2T / HSPC150 Antibody Blocking Peptide - LS-E15887 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2T Recombinant Protein - H00029089-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UBE2T Protein - NBP1-44487 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

UBE2T-Antibody-C-term-Blocking-Peptide - BP17379b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2T blocking peptide - GTX89819-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

UBE2T Protein (OPPA02389) - OPPA02389 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human UBE2T (His Tag) protein - orb232293 from Biorbyt Category Protein Prices $315.00, $476.00 Sizes 50 μg, 200 μg Species Human

Human Ubiquitin Conjugating Enzyme E2T protein - orb90301 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

UBCH1 protein (GST tag) - 80R-2558 from Fitzgerald Category Protein Prices $195.00 Sizes 10 µg Source E.coli Species Human

UBCH5a protein (His tag) - 80R-2539 from Fitzgerald Category Protein Prices $195.00 Sizes 10 µg Source E.coli Species Human

UBE2T protein (His tag) - 80R-1294 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

UBE2T Blocking Peptide - abx063832 from Abbexa Category Peptide Species Human

HSPC150 Peptide - AC21-0304-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UBE2T (1-197, His-tag) - AR09429PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

UBE2T (1-197, His-tag) - AR09429PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

UBE2T - H00029089-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBE2T - H00029089-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Ubiquitin-Conjugating Enzyme E2T, Human Recombinant - 228-12524-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Ubiquitin-Conjugating Enzyme E2T - 228-12524-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Ubiquitin-Conjugating Enzyme E2T - 228-12524-3 from RayBiotech Category Protein Prices $2,400.00 Sizes 3 µg Source Escherichia Coli. Species Human

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