UBE2T

Gene Symbol	UBE2T
Entrez Gene	29089
Alt Symbol	HSPC150, PIG50
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2T
Other Description	HSPC150 protein similar to ubiquitin-conjugating enzyme|cell proliferation-inducing gene 50 protein|ubiquitin carrier protein T|ubiquitin conjugating enzyme|ubiquitin-conjugating enzyme E2 T|ubiquitin-conjugating enzyme E2T (putative)|ubiquitin-protein ligase T
Swissprots	Q2TU36 Q9NPD8
Accessions	CAI84529 EAW91411 EAW91412 EAW91413 EAW91414 EAW91415 Q9NPD8 AB032931 BAA93711 AF160215 AAF67016 AF161499 AAF29114 AK000504 BAA91211 AY542309 AAT08178 BC004152 AAH04152 BC019284 AAH19284 BG776416 DQ892729 ABM83655 DQ895975 ABM86901 NM_014176 NP_054895
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19887602}. Note=Accumulates to chromatin.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® UBE2T siRNA I - 13142 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

UBE2T CRISPR/Cas9 KO Plasmid (h) - sc-405195 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T HDR Plasmid (h) - sc-405195-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T Double Nickase Plasmid (h) - sc-405195-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T Double Nickase Plasmid (h2) - sc-405195-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T CRISPR Activation Plasmid (h) - sc-405195-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T CRISPR Activation Plasmid (h2) - sc-405195-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T Lentiviral Activation Particles (h) - sc-405195-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T Lentiviral Activation Particles (h2) - sc-405195-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2T siRNA (h) - sc-78641 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBE2T shRNA Plasmid (h) - sc-78641-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBE2T shRNA (h) Lentiviral Particles - sc-78641-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBE2T RNAi - H00029089-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU013731 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22386 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22386 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00447 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00447

UBE2T siRNA (Human) - CRH9182 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBE2T - MBS8240550 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UBE2T (NM_014176.3) - SHH439188 from Creative biogene Category siRNA Species Reactivities Human

UBE2T shRNA Plasmid (Human) - CHH9182 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UBE2T miRNA 3'UTR clone - MiUTR3H-11297 from Creative biogene Species Reactivities Human

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