UBE2T

Gene Symbol	UBE2T
Entrez Gene	29089
Alt Symbol	HSPC150, PIG50
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2T
Other Description	HSPC150 protein similar to ubiquitin-conjugating enzyme|cell proliferation-inducing gene 50 protein|ubiquitin carrier protein T|ubiquitin conjugating enzyme|ubiquitin-conjugating enzyme E2 T|ubiquitin-conjugating enzyme E2T (putative)|ubiquitin-protein ligase T
Swissprots	Q2TU36 Q9NPD8
Accessions	CAI84529 EAW91411 EAW91412 EAW91413 EAW91414 EAW91415 Q9NPD8 AB032931 BAA93711 AF160215 AAF67016 AF161499 AAF29114 AK000504 BAA91211 AY542309 AAT08178 BC004152 AAH04152 BC019284 AAH19284 BG776416 DQ892729 ABM83655 DQ895975 ABM86901 NM_014176 NP_054895
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. {ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:19887602, ECO:0000269|PubMed:20061386}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19887602}. Note=Accumulates to chromatin.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UBE2T (D2L7H) Rabbit mAb - 12992 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D2L7H

UBE2T (N-14) - sc-103912 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

UBE2T (T-14) - sc-103913 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

UBE2T (4E5) - sc-100623 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

UBE2T (D-14) - sc-103911 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

UBE2T (H-75) - sc-367592 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-HSPC150 antibody - ab192301 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSPC150 antibody - ab110459 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSPC150 antibody - ab4284 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-HSPC150 antibody - ab57334 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-HSPC150 antibody - ab118931 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HSPC150 antibody [2F5] - ab117918 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2F5

Anti-HSPC150 antibody [EP9447] - ab179802 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP9447

Anti-HSPC150 antibody [EPR9446] - ab140611 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9446

Anti-HSPC150 antibody - C-terminal - ab154022 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa125-154, Biotin) - LS-C218249 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa1-198, clone 10D209, Azide-free) - LS-C183701 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 10D209

Anti-UBE2T / HSPC150 Antibody (aa125-154, AP) - LS-C218248 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa125-154, Azide-free, HRP) - LS-C218251 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa125-154, PE) - LS-C218252 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa125-154, APC) - LS-C221192 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa147-197) - LS-C288652 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa185-197) - LS-C54985 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (aa125-154) - LS-C326140 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2T / HSPC150 Antibody (N-Terminus) - LS-C116226 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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