HDAC3

Gene Symbol	HDAC3
Entrez Gene	8841
Alt Symbol	HD3, RPD3, RPD3-2
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 3
Other Description	SMAP45
Swissprots	O15379 D3DQE1 O43268 Q9UEV0 Q9UEI5
Accessions	AAC08351 AAC08352 AAC26509 BAG70923 EAW61915 EAW61916 EAW61917 EAW61918 O15379 AF005482 AAB87752 AF039703 AAC98927 AY429537 AY429538 BC000614 AAH00614 BM461585 DB456387 DQ891916 ABM82842 DQ895101 ABM86027 U66914 AAC52038 U75696 AAB88240 U75697 AAB88241 XM_011537697 XP_011535999 XR_944336 NM_003883 NP_003874
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with X
Subcellular Location	Nucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}.
Tissue Specificity	Widely expressed.
Top Pathways	Viral carcinogenesis, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Histone Deacetylase (HDAC) Activity Assay Kit (Fluorometric) - ab156064 from Abcam Category Cellular Assay Prices $464.00 Sizes 100 tests

Mouse/Human/Rat Phospho-HDAC3 (Ser424) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1362 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat HDAC3 ELISA Kit (Cell-Based ELISA) - LS-F2039 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Histone deacetylase 3 (HDAC3), Human, ELISA Kit - CSB-E14413h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.39 ng/ml Range 1.56 ng/ml-100 ng/ml

Histone Deacetylase 3, Human, ELISA Kit - E01H0236 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

HDAC3 (Human) IP-WB Antibody Pair - H00008841-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) IP-WB Antibody Pair - H00008841-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) Matched Antibody Pair - H00008841-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) Matched Antibody Pair - H00008841-AP42 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) Matched Antibody Pair - H00008841-AP43 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) Matched Antibody Pair - H00008841-AP44 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) Matched Antibody Pair - H00008841-AP45 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 (Human) Matched Antibody Pair - H00008841-AP46 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC3 Colorimetric Cell-Based ELISA Kit - CB5321 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

HDAC3 (Phospho-Ser424) Colorimetric Cell-Based ELISA Kit - CBP1378 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Histone Deacetylase 3, ELISA Kit - MBS032000 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS038400 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

Histone Deacetylase 3, ELISA Kit - MBS019741 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS019488 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS062240 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS753193 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Histone Deacetylase 3, ELISA Kit - MBS071992 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS040768 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS037974 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 3, ELISA Kit - MBS103255 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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