HDAC3

Gene Symbol HDAC3
Entrez Gene 8841
Alt Symbol HD3, RPD3, RPD3-2
Species Human
Gene Type protein-coding
Description histone deacetylase 3
Other Description SMAP45
Swissprots O15379 D3DQE1 O43268 Q9UEV0 Q9UEI5
Accessions AAC08351 AAC08352 AAC26509 BAG70923 EAW61915 EAW61916 EAW61917 EAW61918 O15379 AF005482 AAB87752 AF039703 AAC98927 AY429537 AY429538 BC000614 AAH00614 BM461585 DB456387 DQ891916 ABM82842 DQ895101 ABM86027 U66914 AAC52038 U75696 AAB88240 U75697 AAB88241 XM_011537697 XP_011535999 XR_944336 NM_003883 NP_003874
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with X
Subcellular Location Nucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}.
Tissue Specificity Widely expressed.
Top Pathways Viral carcinogenesis, Alcoholism

Phospho-HDAC3 (Ser424) Antibody - 3815 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, C6 and C2C12 cells, untreated or λ-phosphatase-treated, using Phospho-HDAC3 (Ser424) Antibody (upper) or HDAC3 Antibody #2632 (lower).

Histone Deacetylase 3 (HDAC3) Antibody - 2632 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS and HeLa cells using Histone Deacetylase 3 (HDAC3) Antibody.

HDAC3 (7G6C5) Mouse mAb - 3949 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 7G6C5
Western blot analysis of extracts from various cell lines using HDAC3 (7G6C5) Mouse mAb.

HDAC3 (A-3) - sc-376957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC3 (A-3): sc-376957. Western blot analysis of HDAC3 expression in U-87 MG whole cell lysate (A) and Jurkat nuclear extract (B).

HDAC3 (3G6) - sc-81600 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC3 (3G6): sc-81600. Western blot analysis of human recombinant HDAC3 fusion protein.

HDAC3 (1) - sc-130319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC3 (1): sc-130319. Western blot analysis of human recombinant HDAC3.

HDAC3 (B-12) - sc-17795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC3 (B-12): sc-17795. Western blot analysis of HDAC3 expression in Jurkat (A), K-562 (B), A-431 (C) and NIH/3T3 (D) nuclear extracts.

HDAC3 (H-99) - sc-11417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HDAC3 (H-99): sc-11417. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

HDAC3 (N-19) - sc-8138 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ChIP analysis of cofactor occupancy dynamics on the <i>KAI1</i> promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, HDAC3 (H-99): sc-11417, HDAC3 (N-19): sc-8138, Bcl-3 (C-14): sc-185, Bcl-3 (H-146): sc-13038. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek <i>et al</i>., Cell 2002, 110: 55-67.

HDAC3 (40) - sc-136290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
HDAC3 (40): sc-136290. Immunofluorescence staining of human endothelial cells showing nuclear localization.

Anti-HDAC3 (phospho S424) antibody - ab61056 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC3 (phospho S424) antibody (ab61056) at 1/500 dilutionLane 1 : NIH/3T3 cell extract with no phosphopeptideLane 2 : NIH/3T3 cell extract with phosphopeptide

Anti-HDAC3 antibody - ab63353 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Standard Curve for HDAC3 (Analyte: HDAC3 protein (Tagged) (ab82071)); dilution range 1 pg/ml to 1 ug/ml using Capture Antibody Mouse monoclonal [7G6C5] to HDAC3 (ab76359) at 5 ug/ml and Detector Antibody Rabbit polyclonal to HDAC3 (ab63353) at 0.5 ug/ml.

Anti-HDAC3 antibody - ab61216 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC3 antibody (ab61216) at 1/500 dilutionLane 1 : extracts from HepG2 cellsLane 2 : extracts from HepG2 cells with immunizing peptide

Anti-HDAC3 antibody [3A7B5] - ab76364 from Abcam

Host Mouse
Clonality Monoclonal
Clone 3A7B5
All lanes : Anti-HDAC3 antibody [3A7B5] (ab76364) at 1/500 dilutionLane 1 : truncated Trx-HDAC3Lane 2 : full length HDAC3-hIgGFcLane 3 : HeLa cell lysate

Anti-HDAC3 antibody [3G6] - C-terminal - ab170199 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G6
Lane 1 : Anti-HDAC3 antibody [3G6] - C-terminal (ab170199) at 1/100 dilutionLane 2 : Anti-HDAC3 antibody [3G6] - C-terminal (ab170199) at 1/200 dilutionLane 3 : Anti-HDAC3 antibody [3G6] - C-terminal (ab170199) at 1/400 dilutionLane 1 : NIH 3T3 cell lysateLane 2 : NIH 3T3 cell lysateLane 3 : NIH 3T3 cell lysate

Anti-HDAC3 antibody [7G6C5] - ab76359 from Abcam

Host Mouse
Clonality Monoclonal
Clone 7G6C5
Standard Curve for HDAC3 (Analyte: HDAC3 protein (Tagged) (ab82071)); dilution range 1 pg/ml to 1 ug/ml using Capture Antibody Mouse monoclonal [7G6C5] to HDAC3 (ab76359) at 5 ug/ml and Detector Antibody Rabbit polyclonal to HDAC3 (ab63353) at 0.5 ug/ml.

Anti-HDAC3 antibody [EP462Y] - ab76295 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP462Y
Anti-HDAC3 antibody [EP462Y] (ab76295) at 1/2000 dilution + HeLa cell lysate at 10 µgSecondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-HDAC3 antibody [Y415] - ab32369 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y415
Anti-HDAC3 antibody [Y415] (ab32369) at 1/10000 dilution + K562 cell lysate

Anti-HDAC3 antibody - ChIP Grade - ab7030 from Abcam

Prices $401.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Sonicated Chromatin prepared from untreated (UI) or 17beta-estradiol (E2) treated MCF7 cells was subjected to the ChIP procedure with ab7030 to HDAC3 and the immunoprecipitated chromatin was analysed in the proximal region of the estrogen-responsive pS2 promoter (as shown above) and quantified by real-time PCR (values are nomalized over inputs). The primers are designed to follow the nucleosome E (including the Estrogen Responsive Element ERE). 2 µl of ab7030 and 2x106 cells were used in each ChIP experiment.

Anti-HDAC3 antibody - ChIP Grade - ab96005 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HDAC3 antibody - ChIP Grade (ab96005) at 1/2000 dilution + HeLa

Anti-HDAC3 Antibody (C-Terminus) - LS-C7406 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HDAC3 Antibody (aa411-428) - LS-C7407 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HDAC3 Antibody (aa313-428) - LS-C7410 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC3 Antibody (aa411-428) - LS-C7409 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-HDAC3 Antibody (aa224-428, clone 3A7B5) IHC-plus™ - LS-B3893 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3A7B5
Anti-HDAC3 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3893 dilution 1:200.
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