| Gene Symbol | HDAC3 |
|---|---|
| Entrez Gene | 8841 |
| Alt Symbol | HD3, RPD3, RPD3-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | histone deacetylase 3 |
| Other Description | SMAP45 |
| Swissprots | O15379 D3DQE1 O43268 Q9UEV0 Q9UEI5 |
| Accessions | AAC08351 AAC08352 AAC26509 BAG70923 EAW61915 EAW61916 EAW61917 EAW61918 O15379 AF005482 AAB87752 AF039703 AAC98927 AY429537 AY429538 BC000614 AAH00614 BM461585 DB456387 DQ891916 ABM82842 DQ895101 ABM86027 U66914 AAC52038 U75696 AAB88240 U75697 AAB88241 XM_011537697 XP_011535999 XR_944336 NM_003883 NP_003874 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with X |
| Subcellular Location | Nucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Viral carcinogenesis, Alcoholism |
HDAC3 CRISPR/Cas9 KO Plasmid (h) - sc-400446 from Santa Cruz Biotechnology
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HDAC3 HDR Plasmid (h) - sc-400446-HDR from Santa Cruz Biotechnology
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HDAC3 Double Nickase Plasmid (h) - sc-400446-NIC from Santa Cruz Biotechnology
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HDAC3 Double Nickase Plasmid (h2) - sc-400446-NIC-2 from Santa Cruz Biotechnology
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HDAC3 CRISPR Activation Plasmid (h) - sc-400446-ACT from Santa Cruz Biotechnology
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HDAC3 CRISPR Activation Plasmid (h2) - sc-400446-ACT-2 from Santa Cruz Biotechnology
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HDAC3 Lentiviral Activation Particles (h) - sc-400446-LAC from Santa Cruz Biotechnology
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HDAC3 Lentiviral Activation Particles (h2) - sc-400446-LAC-2 from Santa Cruz Biotechnology
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HDAC3 siRNA (h) - sc-35538 from Santa Cruz Biotechnology
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HDAC3 shRNA Plasmid (h) - sc-35538-SH from Santa Cruz Biotechnology
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HDAC3 shRNA (h) Lentiviral Particles - sc-35538-V from Santa Cruz Biotechnology
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HDAC3 RNAi - H00008841-R01 from Novus Biologicals
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MISSION® esiRNA - EHU035581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2181 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05427 from Sigma-Aldrich
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HDAC3 siRNA (Human) - CRH5837 from Cohesion Biosciences
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HDAC3 - MBS8202489 from MyBioSource
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shRNA set against Human HDAC3 (NM_003883.3) - SHH310981 from Creative biogene
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shRNA set against Human HDAC3(NM_003883.3) - SHH116291 from Creative biogene
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Human HDAC3 siRNA - orb266339 from Biorbyt
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HDAC3 shRNA Plasmid (Human) - CHH5837 from Cohesion Biosciences
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HDAC3 miRNA 3'UTR clone - MiUTR1H-04415 from Creative biogene
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