HDAC3

Gene Symbol	HDAC3
Entrez Gene	8841
Alt Symbol	HD3, RPD3, RPD3-2
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 3
Other Description	SMAP45
Swissprots	O15379 D3DQE1 O43268 Q9UEV0 Q9UEI5
Accessions	AAC08351 AAC08352 AAC26509 BAG70923 EAW61915 EAW61916 EAW61917 EAW61918 O15379 AF005482 AAB87752 AF039703 AAC98927 AY429537 AY429538 BC000614 AAH00614 BM461585 DB456387 DQ891916 ABM82842 DQ895101 ABM86027 U66914 AAC52038 U75696 AAB88240 U75697 AAB88241 XM_011537697 XP_011535999 XR_944336 NM_003883 NP_003874
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with X
Subcellular Location	Nucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}.
Tissue Specificity	Widely expressed.
Top Pathways	Viral carcinogenesis, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active HDAC3+NCOR2 complex full length protein - ab42631 from Abcam Category Protein Prices $466.00 Sizes 50 µg Source Baculovirus

Active human HDAC3 full length protein - ab101663 from Abcam Category Protein Source Baculovirus Species Human

Active human HDAC3+NCOR2 complex full length protein - ab179493 from Abcam Category Protein Prices $361.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human HDAC3 full length protein - ab82071 from Abcam Category Protein Source Baculovirus Species Human

Human HDAC3 peptide - ab16279 from Abcam Category Peptide

HDAC3 Antibody Blocking Peptide - LS-E2335 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC3 Antibody Blocking Peptide - LS-E15745 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HDAC3 Protein - H00008841-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HDAC3 Protein - H00008841-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HDAC3 Protein - NBP1-99605 from Novus Biologicals Category Protein Prices $295.00 Sizes 250 tests Source Sf9 insect cells Species Human

HDAC3 Protein - NBP1-99777 from Novus Biologicals Category Protein Species Human

HDAC3-Antibody-C-term-Blocking-peptide - BP13297b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human HD 3 protein - orb84485 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Insect Species Human

Human HDAC3 protein - orb244265 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

HDAC3 peptide - orb218193 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Cat

HDAC 3 Blocking Peptide - 33R-10518 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

Hdac3 Blocking Peptide - 33R-2222 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HDAC3 Blocking Peptide - 33R-10828 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Histone Deacetylase 3 Blocking Peptide - abx063524 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig

HDAC3 - H00008841-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HDAC3 - H00008841-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HDAC3 - H00008841-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HDAC3 - H00008841-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HDAC3 control peptide - AP00272CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

HDAC3 control peptide - SP5322CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

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